Synthesis, structural characterization, biological activity, and theoretical studies of some novel thioether‐bridged 2, 6‐disubstituted imidazothiadiazole analogues
Yazarlar (6)
Hasan Tunel Karabük Üniversitesi, Türkiye
Mustafa Er Karabük Üniversitesi, Türkiye
Hakan Alıcı Zonguldak Bülent Ecevit Üniversitesi, Türkiye
Abdurrahman Onaran Akdeniz Üniversitesi, Türkiye
Prof. Dr. Tuncay KARAKURT Kırşehir Ahi Evran Üniversitesi, Türkiye
Hakan Tahtacı Karabük Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Heterocyclic Chemistry | ||
| Dergi ISSN | 0022-152X Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2021 |
| Kabul Tarihi | 12-04-2026 | Yayınlanma Tarihi | – |
| Cilt / Sayı / Sayfa | 58 / 6 / 1321–1343 | DOI | 10.1002/jhet.4260 |
| Makale Linki | http://dx.doi.org/10.1002/jhet.4260 | ||
| Özet |
| In this study, thioether‐bridged imidazo[2,1‐b][1,3,4]thiadiazole derivatives that contained both imidazole and 1,3,4‐thiadiazole (compounds 7a‐7i and 8a‐8i) were synthesized from the reactions of 2‐amino‐1,3,4‐thiadiazole with phenacyl bromide (6a‐6i) (at yields of 59% to 74%). The structure of the synthesized compounds was characterized using 1H NMR, 13C NMR, Fourier‐transform infrared spectroscopy, elemental analysis, mass spectroscopy, and X‐ray diffraction analysis. Mycelial growth, mycelial growth inhibition, minimum inhibitory concentration, minimum fungicidal concentration, and lethal dose values against various plant pathogenic fungi were determined for all of the target compounds synthesized in the study. The test results showed that most of the compounds had moderate to good antifungal activity. In addition, the absorption, distribution, metabolism, excretion (ADME) parameters of the … |
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BM Sürdürülebilir Kalkınma Amaçları
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| Google Scholar | 20 |
| Scopus | 9 |
| Web of Science | 18 |