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Copper Triflate Catalyzed Regioselective Alkylation of Pyrrole Conversion of 2 Alkylated Pyrroles to Novel Pyrrolizine Derivatives by Self Cyclization   
Yazarlar (3)
Canan Ünaleroğlu
Hacettepe Üniversitesi, Türkiye
Dr. Öğr. Üyesi Sertan AYTAÇ Dr. Öğr. Üyesi Sertan AYTAÇ
Kırşehir Ahi Evran Üniversitesi, Türkiye
Barış Temelli
Hacettepe Üniversitesi, Türkiye
Devamını Göster
Özet
Metal triflate catalyzed addition reaction of pyrrole to methyl 2-oxo-4-phenylbut-3-enoate and substituted derivatives generated the related novel alkylated pyrroles regioselectively at C (2) of pyrrole. Among the studied metal triflates, Cu (OTf) 2 was found to be more effective in the addition reaction. The synthesized methyl 2-oxo-4-phenyl-4-(1H-pyrrole-2-yl) butanoate esters underwent self-cyclization by heating and yielded the corresponding methyl 3-hydroxy-1-phenyl-2, 3-dihydro-1H-pyrrolizine-3-carboxylate and substituted derivatives. This reaction procedure allowed easy access to pyrrolizine structure in mild reaction conditions.
Anahtar Kelimeler
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale
Dergi Adı HETEROCYCLES
Dergi ISSN 0385-5414 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q3
Makale Dili İngilizce
Basım Tarihi 01-2007
Cilt No 71
Sayı 11
Sayfalar 2427 / 2440
Doi Numarası 10.1002/chin.200811116
Makale Linki https://www.heterocycles.jp/newlibrary/payments/form/02463/PDF