Copper Triflate Catalyzed Regioselective Alkylation of Pyrrole: Conversion of 2‐Alkylates Pyrroles to Novel Pyrrolizine Derivatives by Self‐Cyclization.
Yazarlar (3)
Hacettepe Üniversitesi, Türkiye
Doç. Dr. Sertan AYTAÇ
Kırşehir Ahi Evran Üniversitesi, Türkiye
Hacettepe Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | HETEROCYCLES (Q3) | ||
| Dergi ISSN | 0385-5414 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2007 |
| Cilt / Sayı / Sayfa | 71 / 11 / 2427–2440 | DOI | 10.3987/COM-07-11137 |
| Makale Linki | https://doi.org/10.1002/chin.200811116 | ||
| Özet |
| Metal triflate catalyzed addition reaction of pyrrole to methyl 2-oxo-4-phenylbut-3-enoate and substituted derivatives generated the related novel alkylated pyrroles regioselectively at C (2) of pyrrole. Among the studied metal triflates, Cu (OTf) 2 was found to be more effective in the addition reaction. The synthesized methyl 2-oxo-4-phenyl-4-(1H-pyrrole-2-yl) butanoate esters underwent self-cyclization by heating and yielded the corresponding methyl 3-hydroxy-1-phenyl-2, 3-dihydro-1H-pyrrolizine-3-carboxylate and substituted derivatives. This reaction procedure allowed easy access to pyrrolizine structure in mild reaction conditions. |
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BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 19 |
| Google Scholar | 24 |