Effect of Doxorubicin loaded CS MNPs on cell proliferation in sensitive and Doxorubicin resistant MCF 7 cell lines
Yazarlar (7)
G. Unsoy
Middle East Technical University, Türkiye
R. Khodadust
Middle East Technical University, Türkiye
Prof. Dr. Serap YALÇIN AZARKAN
Kırşehir Ahi Evran Üniversitesi, Türkiye
P. Mutlu
Middle East Technical University, Türkiye
N. Taghavi Pourianazar
Middle East Technical University, Türkiye
M. Parsian
Middle East Technical University, Türkiye
U. Gunduz
Middle East Technical University, Türkiye
| Bildiri Türü |
Tebliğ/Bildiri
|
Bildiri Dili | İngilizce |
| Bildiri Alt Türü | Poster Olarak Sergilenen Tebliğ (Uluslararası Kongre/Sempozyum) | ||
| Bildiri Niteliği | Web of Science Kapsamındaki Kongre/Sempozyum | ||
| DOI Numarası | 10.1111/febs.12919 | ||
| Kongre Adı | FEBS EMBO 2014 | ||
| Kongre Tarihi | 30-08-2014 / 04-09-2014 | ||
| Basıldığı Ülke | Fransa | Basıldığı Şehir | Paris |
| Özet |
| Background: Dose-and time-dependent effects of doxorubicin on telomerase activity (TA) and expression levels of hTERT, Bcl-2, Bcl-x (L) and Bax were investigated in doxorubicin-resistant and-sensitive MCF-7 cells. Methods: Doxorubicin-resistant MCF-7/R was developed from sensitive MCF-7 breast carcinoma cell line and acquired resistance was demonstrated by XTT and mRNA analysis of MDR1 and MRP1 genes. Expression levels were determined by RT-PCR. Newly developed rapid and simple TRAP-silver staining assay w... |
| Anahtar Kelimeler |
| Doxorubicin | drug resistance | breast cancer | cytotoxicity |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |