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Effect of Doxorubicin loaded CS MNPs on cell proliferation in sensitive and Doxorubicin resistant MCF 7 cell lines    
Yazarlar (7)
G. Unsoy
R. Khodadust
Prof. Dr. Serap YALÇIN AZARKAN Prof. Dr. Serap YALÇIN AZARKAN
Kırşehir Ahi Evran Üniversitesi, Türkiye
P. Mutlu
N. Taghavi Pourianazar
M. Parsian
U. Gunduz
Devamını Göster
Özet
Background: Dose-and time-dependent effects of doxorubicin on telomerase activity (TA) and expression levels of hTERT, Bcl-2, Bcl-x (L) and Bax were investigated in doxorubicin-resistant and-sensitive MCF-7 cells. Methods: Doxorubicin-resistant MCF-7/R was developed from sensitive MCF-7 breast carcinoma cell line and acquired resistance was demonstrated by XTT and mRNA analysis of MDR1 and MRP1 genes. Expression levels were determined by RT-PCR. Newly developed rapid and simple TRAP-silver staining assay w...
Anahtar Kelimeler
Doxorubicin | drug resistance | breast cancer | cytotoxicity
Bildiri Türü Tebliğ/Bildiri
Bildiri Alt Türü Poster Olarak Sergilenen Tebliğ (Uluslararası Kongre/Sempozyum)
Bildiri Niteliği Web of Science Kapsamındaki Kongre/Sempozyum
Bildiri Dili İngilizce
Kongre Adı FEBS EMBO 2014
Kongre Tarihi 30-08-2014 / 04-09-2014
Basıldığı Ülke Fransa
Basıldığı Şehir Paris