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Prof. Dr. Serap YALÇIN AZARKAN
Kırşehir Ahi Evran Üniversitesi, Türkiye |
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| Özet |
| Background: Dose-and time-dependent effects of doxorubicin on telomerase activity (TA) and expression levels of hTERT, Bcl-2, Bcl-x (L) and Bax were investigated in doxorubicin-resistant and-sensitive MCF-7 cells. Methods: Doxorubicin-resistant MCF-7/R was developed from sensitive MCF-7 breast carcinoma cell line and acquired resistance was demonstrated by XTT and mRNA analysis of MDR1 and MRP1 genes. Expression levels were determined by RT-PCR. Newly developed rapid and simple TRAP-silver staining assay w... |
| Anahtar Kelimeler |
| Doxorubicin | drug resistance | breast cancer | cytotoxicity |
| Bildiri Türü | Tebliğ/Bildiri |
| Bildiri Alt Türü | Poster Olarak Sergilenen Tebliğ (Uluslararası Kongre/Sempozyum) |
| Bildiri Niteliği | Web of Science Kapsamındaki Kongre/Sempozyum |
| Bildiri Dili | İngilizce |
| Kongre Adı | FEBS EMBO 2014 |
| Kongre Tarihi | 30-08-2014 / 04-09-2014 |
| Basıldığı Ülke | Fransa |
| Basıldığı Şehir | Paris |