The cytotoxic analysis of free Doxorubicin and Doxorubicin loaded PHB MNPs on sensitive and Doxorubicin resistant MCF 7 cell lines
Yazarlar (7)
Prof. Dr. Serap YALÇIN AZARKAN Kırşehir Ahi Evran Üniversitesi, Türkiye
G. Unsoy
P. Mutlu
R. Khodadust
N. Taghavi Pourianazar
M. Parsian
U. Gunduz
| Bildiri Türü |
Tebliğ/Bildiri
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Bildiri Dili | İngilizce |
| Bildiri Alt Türü | Poster Olarak Sergilenen Tebliğ (Uluslararası Kongre/Sempozyum) | ||
| Bildiri Niteliği | Web of Science Kapsamındaki Kongre/Sempozyum | ||
| DOI Numarası | 10.1111/febs.12919 | ||
| Kongre Adı | FEBS EMBO 2014 | ||
| Kongre Tarihi | 30-08-2014 / 04-09-2014 | ||
| Basıldığı Ülke | Fransa | Basıldığı Şehir | Paris |
| UAK Araştırma Alanları |
Toksikoloji
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| Özet |
| Doxorubicin is an antracycline antibiotic. It is a commonly used anticancer agent in many cancer types and its most serious side effect is damaging the heart cells. Therefore targeting of this chemotherapeutic agent with a suitable nano carrier mediated drug delivery system is important. Aim of this study, the cytotoxic effect of free Doxorubicin and Doxorubicin coated MNPs were compared on sensitive and Doxorubicin resistant breast cancer MCF-7 cells. In this study, Polyhydroxybutyrate (PHB) coated magnetic nanoparticles (PHB-MNPs) were synthesized by in situ coating method. Doxorubicin was loaded onto the PHB-MNPs. Cytotoxicity analysis of Doxorubicin loaded PHB-MNPs were performed on Doxorubicin resistant MCF-7 breast cancer cells. The cytotoxicity levels of free Doxorubicin and Doxorubicin loaded MNPs on both of the cell lines were tested by XTT cell proliferation assay. Doxorubicin loaded PHB … |
| Anahtar Kelimeler |
| Doxorubicin | drug resistance | breast cancer | cytotoxicity |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 1 |