Magnetic half generation PAMAM dendrimeric nanoparticles for targeting delivery of Gemcitabine
Yazarlar (5)
Prof. Dr. Serap YALÇIN AZARKAN
Kırşehir Ahi Evran Üniversitesi, Türkiye
Ayşen Tezcaner
Orta Doğu Teknik Üniversitesi, Türkiye
Ufuk Gündüz
Orta Doğu Teknik Üniversitesi, Türkiye
| Bildiri Türü | Tebliğ/Bildiri | Bildiri Dili | İngilizce |
| Bildiri Alt Türü | Poster Olarak Sergilenen Tebliğ (Uluslararası Kongre/Sempozyum) | ||
| Bildiri Niteliği | Alanında Hakemli Uluslararası Kongre/Sempozyum | ||
| Kongre Adı | 11th International Symposium on Pharmaceutical Sciences (ISOPS) | ||
| Kongre Tarihi | 09-06-2015 / 12-06-2015 | ||
| Basıldığı Ülke | Basıldığı Şehir | ||
| Özet |
| Antitumor activity of Gemcitabine, a nucleoside analogue, has been reported in a variety of human tumors, including breast cancer in both experimental and clinical studies. Conventional chemotherapeutic agents are unspecifically distributed all over the body where they affect both cancerous and normal cells. They cause major systemic toxicities and drug resistance, which also restricts drugs therapeutic efficacy. Recent advances in nanotechnology have explored new targeting strategies for enhancing intra-tumoral drug concentrations while limiting the systemic toxicity and side effects. Controlled release of Gemcitabine within cancer cells could be achieved by PAMAM coated magnetic nanoparticles (DcMNPs) which could be targeted to the tumor tissue. |
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