The Cytotoxic Effect of Annona muricata Leaf Extract on Triple Negative Breast Cancer Cell Line.
Yazarlar (2)
Prof. Dr. Serap YALÇIN AZARKAN
Kırşehir Ahi Evran Üniversitesi, Türkiye
| Bildiri Türü | Tebliğ/Bildiri | Bildiri Dili | İngilizce |
| Bildiri Alt Türü | Özet Metin Olarak Yayınlanan Tebliğ (Uluslararası Kongre/Sempozyum) | ||
| Bildiri Niteliği | Alanında Hakemli Uluslararası Kongre/Sempozyum | ||
| Kongre Adı | 2nd International Conference on Natural Products for Cancer Prevention and Therapy | ||
| Kongre Tarihi | 08-11-2017 / 10-11-2017 | ||
| Basıldığı Ülke | Basıldığı Şehir | ||
| Özet |
| Annona muricata, also known as soursop, has been reported to show cytotoxic activities against cancer cell lines. In this study, we evaluated the antiproliferative effect of Annona muricata leaf extract on the triple negative breast cancer cell line (MDA-MB-231). The antiproliferative effects of leaf extracts on MDA-MB-231cell line were evaluated by means of cell proliferation assay with XTT Reagent (Biological Industries, Israel). The assay was a colorimetric test based on the reduction tetrazolium salt, XTT to colored formazan products by mitochondria of live cells. In brief, cells were seeded into 96-well microtiter plates (Greiner) at a concentration of 5.0 × 104 cells/well and incubated for 72 h in medium containing horizontal dilutions of leaf extract. In each plate, the assay was performed with a column of blank medium control and a cell control column. Then, XTT reagent was added and the soluble product was … |
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