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Investigation of interleukin 18 polymorphism in hepatit B virus carriers chronic hepatitis and cirrhosis patients   
Yazarlar (3)
Yalcin Serap
Demirbas Seref
Onguru Onder
Devamını Göster
Özet
Hepatitis B virus (HBV) infection is a majority problem of public health in the world. An estimated 350-400 million people worldwide are chronically infected with HBV [1, 2]. Wang et al.[3] have reported approximately 250,000 deaths to happen each year as a consequence of hepatic failure, cirrhosis and hepatocellular carcinoma.The cytokine-mediated immunity plays a crucial role in determining of hepatitis infections overcome. The variations in cytokine production may influence the outcome of cytokinebased immunotherapy [4, 5]. Cytokine gene polymorphisms were associated with the severity of the liver disease in patients with HBV infection [6]. Interleukin (IL)-18 is a pleiotropic proinflammatory cytokine. It is a member of the IL-1 family and was first identified as interferon-gamma inducing factor [7-9]. IL-18 is synthesized as a 24-kDa proform which is activated to
Anahtar Kelimeler
Makale Türü Özgün Makale
Makale Alt Türü Diğer hakemli uluslarası dergilerde yayınlanan tam makale
Dergi Adı Journal of Experimental and Integrative Medicine
Dergi ISSN 1309-4572 Scopus Dergi
Dergi Tarandığı Indeksler EBSCO, DOAJ, ScopeMed, Index Scholar, Akademik Dizin
Makale Dili İngilizce
Basım Tarihi 01-2014
Cilt No 4
Sayı 3
Sayfalar 175 /
Doi Numarası 10.5455/jeim.150514.or.105
Makale Linki http://www.scopemed.org/?mno=158328