PAMAM dendrimer coated MNPs for siRNA delivery and gene silencing
Yazarlar (7)
| Makale Türü | Özgün Makale (Diğer hakemli uluslarası dergilerde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Cancer Studies and Therapy | ||
| Dergi ISSN | 0101-0001 | ||
| Dergi Tarandığı Indeksler | ScienceScript Open Access | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2014 |
| Cilt / Sayı / Sayfa | 1 / 1 / 1–5 | DOI | – |
| Özet |
| In this study, superparamagnetic iron oxide nanoparticles were synthesized by co-precipitation method. The synthesized nanoparticles were modified with aminopropyl-trimethoxysilane for dendrimer coating. Aminosilane-modified MNPs were coated with PAMAM dendrimer. Gene silencing effect of Survivin siRNA loaded nanoparticles (NPs) were studied on Doxorubicin resistant MCF-7 cell lines. Consequently, Survivin siRNA were triggered cell death when delivered by G4 PAMAM dendrimer coated magnetic nanoparticles. Survivin siRNA loaded G4 MNPs facilitate to overcome drug resistance on Doxorubicin resistant breast cancer cells. |
| Anahtar Kelimeler |
