| Yazarlar |
Pelin Mutlu
|
Serap YALÇIN AZARKAN
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Pinar Elci
|
|
Murat Yildirim
|
|
A. Turker Cetin
|
|
Ferit Avcu
|
| Özet |
| Purpose: The purpose of this study was to evaluate the relationship between -174G/C interleukin-6 (IL-6) gene promoter polymorphism and susceptibility to chronic lymphocytic (CLL), chronic myelogenous (CML) and acute myelogenous leukemia (AML) in Turkish patients. Methods: The frequencies of -174G/C polymorphism were studied in 23 unrelated CLL, 25 CML and 17 AML patients and 30 healthy individuals. Single nucleotide polymorphisms (SNPs) were genotyped by the PCR-RFLP method. Results: A higher prevalence of the C allele was found in CLL, CML and AML patients. However, there were no statistically significant differences regarding either the genotype or the allelic frequencies of the -174G/C polymorphism between CLL, CML and AML cases. Conclusions: These results indicate that C allele is associated with risk of CLL, CML and AML susceptibility in Turkish patients. |
| Anahtar Kelimeler |
| -174G/C | IL-6 | leukemia | single nucleotide polymorphisms |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | JOURNAL OF BUON |
| Dergi ISSN | 1107-0625 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 07-2014 |
| Cilt No | 19 |
| Sayı | 3 |
| Sayfalar | 787 / 791 |
