Association of 174G C interleukin 6 gene polymorphism with the risk of chronic lymphocytic chronic myelogenous and acute myelogenous leukemias in Turkish patients
Yazarlar (6)
Middle East Technical University, Türkiye
Prof. Dr. Serap YALÇIN AZARKAN
Kırşehir Ahi Evran Üniversitesi, Türkiye
Gulhane Training & Research Hospital, Türkiye
Gulhane Training & Research Hospital, Türkiye
Gulhane Training & Research Hospital, Türkiye
Gulhane Training & Research Hospital, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | JOURNAL OF BUON | ||
| Dergi ISSN | 1107-0625 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2014 |
| Cilt / Sayı / Sayfa | 19 / 3 / 787–791 | DOI | – |
| Özet |
| Purpose: The purpose of this study was to evaluate the relationship between -174G/C interleukin-6 (IL-6) gene promoter polymorphism and susceptibility to chronic lymphocytic (CLL), chronic myelogenous (CML) and acute myelogenous leukemia (AML) in Turkish patients. Methods: The frequencies of -174G/C polymorphism were studied in 23 unrelated CLL, 25 CML and 17 AML patients and 30 healthy individuals. Single nucleotide polymorphisms (SNPs) were genotyped by the PCR-RFLP method. Results: A higher prevalence of the C allele was found in CLL, CML and AML patients. However, there were no statistically significant differences regarding either the genotype or the allelic frequencies of the -174G/C polymorphism between CLL, CML and AML cases. Conclusions: These results indicate that C allele is associated with risk of CLL, CML and AML susceptibility in Turkish patients. |
| Anahtar Kelimeler |
| -174G/C | IL-6 | leukemia | single nucleotide polymorphisms |
