Interleukin 6 174G C promoter polymorphism in patients infected by hepatitis B virus
Yazarlar (3)
Serap Yalcin
Seref Demirbas
Onder Onguru
| Makale Türü | Özgün Makale (Diğer hakemli uluslarası dergilerde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Experimental and Integrative Medicine | ||
| Dergi ISSN | 1309-4572 | ||
| Dergi Tarandığı Indeksler | EBSCO, DOAJ, ScopeMed, IndexScholar, Akademik Dizin | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2012 |
| Cilt / Sayı / Sayfa | – / 2 / 1– | DOI | 10.5455/jeim.230112.or.022 |
| Makale Linki | http://www.scopemed.org/?mno=13117 | ||
| UAK Araştırma Alanları |
Toksikoloji
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| Özet |
| Abstract Objective: Hepatitis B virus (HBV) infection is one of the most important health problems in the world. Interleukin-6 (IL-6) has been shown to be a major inflammatory cytokine, inducing cell proliferation and expression of acute response genes, such as fibrinogen and C-reactive protein in hepatocytes. IL-6 levels are elevated in patients acutely infected with HBV and have been associated with progression of infection to chronic hepatitis. Methods: In the present study, the role of IL-6 (-174G/C) polymorphism was investigated on individuals which are diagnosed as hepatitis B virus carrier (n= 19), chronic hepatitis (n= 10) and cirrhosis (n= 13), and non-infected individuals with HBV (n= 8). In order to determine IL-6 polymorphism, the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was applied using genomic DNA extracted from paraffin embedded liver needle biopsy … |
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BM Sürdürülebilir Kalkınma Amaçları
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| Google Scholar | 4 |