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Yalcin Serap
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| Özet |
| Abstract Objective: Hepatitis B virus (HBV) infection is one of the most important health problems in the world. Interleukin-6 (IL-6) has been shown to be a major inflammatory cytokine, inducing cell proliferation and expression of acute response genes, such as fibrinogen and C-reactive protein in hepatocytes. IL-6 levels are elevated in patients acutely infected with HBV and have been associated with progression of infection to chronic hepatitis. Methods: In the present study, the role of IL-6 (-174G/C) polymorphism was investigated on individuals which are diagnosed as hepatitis B virus carrier (n= 19), chronic hepatitis (n= 10) and cirrhosis (n= 13), and non-infected individuals with HBV (n= 8). In order to determine IL-6 polymorphism, the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was applied using genomic DNA extracted from paraffin embedded liver needle biopsy … |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Diğer hakemli uluslarası dergilerde yayınlanan tam makale |
| Dergi Adı | Journal of Experimental and Integrative Medicine |
| Dergi ISSN | 1309-4572 Scopus Dergi |
| Dergi Tarandığı Indeksler | EBSCO, DOAJ, ScopeMed, IndexScholar, Akademik Dizin |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2012 |
| Sayfalar | 1 / |
| Doi Numarası | 10.5455/jeim.230112.or.022 |
| Makale Linki | http://www.scopemed.org/?mno=13117 |
| Atıf Sayıları | |
| Google Scholar | 3 |
