| Yazarlar |
Khodadust Rouhollah
|
|
Mutlu Pelin
|
|
Yalcın Serap
|
|
Unsoy Gozde
|
|
Gunduz Ufuk
|
| Özet |
| Poly (I:C), which is a synthetic double-stranded RNA, have significant toxicity on tumor cells. The immobilization of Poly (I:C) onto nanoparticles is important for the fabrication of targeted delivery systems. In this study, different generations of newly synthesized PAMAM dendron-coated magnetic nanoparticles (DcMNP) which can be targeted to the tumor site under magnetic field were efficiently loaded for the first time with Poly (I:C). Different generations of DcMNPs (G(2), G(3), G(4), G(5), G(6), and G(7)) were synthesized. Poly (I:C) activation was achieved in the presence of EDC and 1-methylimidazole. Loading of Poly (I:C) onto DcMNPs was followed by agarose gel electrophoresis. Acidic reaction conditions were found as superior to basic and neutral for binding of Poly (I:C). In addition, having more functional groups at the surface, higher generations (G(7), G(6), and G(5)) of PAMAM DcMNPs were found more suitable as a delivery system for Poly (I:C). Further in vitro and in vivo analyses of Poly (I:C)/PAMAM magnetic nanoparticles may provide new opportunities for the selective targeting and killing of tumor cells. |
| Anahtar Kelimeler |
| Poly (I:C), Magnetic nanoparticles, Targeted delivery system, Cancer therapy |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Journal of Nanoparticle Research |
| Dergi ISSN | 1388-0764 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 08-2013 |
| Cilt No | 15 |
| Sayı | 8 |
| Doi Numarası | 10.1007/s11051-013-1860-6 |
| Makale Linki | http://link.springer.com/10.1007/s11051-013-1860-6 |
| Atıf Sayıları | |
| WoS | 2 |
| Google Scholar | 7 |
