| Yazarlar (6) |
Unsoy Gozde
|
Prof. Dr. Serap YALÇIN AZARKAN
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Khodadust Rouhollah
|
|
Mutlu Pelin
|
|
Onguru Onder
|
|
Gunduz Ufuk
|
| Özet |
| The use of nanotechnology in cancer treatment offers exciting opportunities, including the possibility of destroying tumors with minimal damage to healthy tissue by novel targeted drug delivery systems. pH differences between healthy and tumor microenvironment provide pH responsive release of drugs at tumor site via smart nanoparticles. In this study, chitosan coated superparamagnetic iron oxide nanoparticles (CS MNPs) were in situ synthesized by ionic crosslinking method as nanocarrier systems and loaded with the drug Bortezomib (Velcade®). The drug loading capacity, drug release and stability of CS MNPs were analyzed. CS MNPs were visualized inside the cells by fluorescence microscopy. The cytotoxicity of Bortezomib, CS MNPs and Bortezomib loaded CS MNPs were tested by XTT analyses in vitro. Gene expression analyses revealed that pro-apoptotic PUMA and NOXA genes were upregulated … |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Biomedicine & Pharmacotherapy |
| Dergi ISSN | 0753-3322 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 06-2014 |
| Cilt No | 68 |
| Sayı | 5 |
| Sayfalar | 641 / 648 |
| Doi Numarası | 10.1016/j.biopha.2014.04.003 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S0753332214000511 |
| Atıf Sayıları | |
| Google Scholar | 91 |
