Doxorubicin loading release and stability of polyamidoamine dendrimer coated magnetic nanoparticles
Yazarlar (5)
Khodadust Rouhollah
Middle East Technical University, Türkiye
Middle East Technical University, Türkiye
Mutlu Pelin
Middle East Technical University, Türkiye
Middle East Technical University, Türkiye
Prof. Dr. Serap YALÇIN AZARKAN Kırşehir Ahi Evran Üniversitesi, Türkiye
Unsoy Gozde
Middle East Technical University, Türkiye
Middle East Technical University, Türkiye
Gunduz Ufuk
Middle East Technical University, Türkiye
Middle East Technical University, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | JOURNAL OF PHARMACEUTICAL SCIENCES | ||
| Dergi ISSN | 0022-3549 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2013 |
| Cilt / Sayı / Sayfa | 102 / 6 / 1825–1835 | DOI | 10.1002/jps.23524 |
| Makale Linki | http://doi.wiley.com/10.1002/jps.23524 | ||
| Özet |
| Nanotechnology is a promising alternative to overcome the limitations of classical chemotherapy. As a novel approach, dendrimer-coated magnetic nanoparticles (DcMNPs) maintain suitable drug delivery system because of their buildup of functional groups, symmetry perfection, nanosize, and internal cavities. They can also be targeted to the tumor site in a magnetic field. The aim of this study is to obtain an effective targeted delivery system for doxorubicin, using polyamidoamine (PAMAM) DcMNPs. Different generations (G2, G3, G4, and G7) of PAMAM DcMNPs were synthesized. Doxorubicin loading, release, and stability efficiencies in these nanoparticles (NPs) were studied. The results showed that low-generation NPs obtained in this study have pH-sensitive drug release characteristics. G4DcMNP, which releases most of the drug in lower pH, seems to be the most suitable generation for efficient Doxorubicin … |
| Anahtar Kelimeler |
| cancer | PAMAM dendrimer-coated magnetic nanoparticles | targeted drug delivery | doxorubicin | controlled release | stability | drug delivery system |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 44 |
| Google Scholar | 66 |