Synthesis of Doxorubicin loaded magnetic chitosan nanoparticles for pH responsive targeted drug delivery
Yazarlar (5)
Unsoy Gozde
Khodadust Rouhollah
Prof. Dr. Serap YALÇIN AZARKAN Kırşehir Ahi Evran Üniversitesi, Türkiye
Mutlu Pelin
Ufuk Gündüz
Orta Doğu Teknik Üniversitesi, Türkiye
Orta Doğu Teknik Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | ||
| Dergi ISSN | 0928-0987 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2014 |
| Cilt / Sayı / Sayfa | 62 / 0 / 243–250 | DOI | 10.1016/j.ejps.2014.05.021 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S0928098714002267 | ||
| Özet |
| Targeted drug delivery is a promising alternative to overcome the limitations of classical chemotherapy. In an ideal targeted drug delivery system carrier nanoparticles would be directed to the tumor tissue and selectively release therapeutic molecules. As a novel approach, chitosan coated magnetic nanoparticles (CS MNPs) maintain a pH dependent drug delivery which provides targeting of drugs to the tumor site under a magnetic field. Among various materials, chitosan has a great importance as a pH sensitive, natural, biodegradable, biocompatible and bioadhesive polymer. The aim of this study was to obtain an effective targeted delivery system for Doxorubicin, using chitosan coated MNPs. Different sized CS MNPs were produced by in situ synthesis method. The anti-cancer agent Doxorubicin was loaded onto CS MNPs which were characterized previously. Doxorubicin loading was confirmed by FTIR. Drug … |
| Anahtar Kelimeler |
| Targeted drug delivery | Doxorubicin | Chitosan | Magnetic nanoparticles |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 290 |
| Google Scholar | 386 |