Simultaneous Headspace GC FID analysis for methanol and ethanol in blood saliva and urine Validation of method and comparison of specimens
Yazarlar (8)
Mergen Gorkem
Kayaalti Zeliha
Prof. Dr. Emrah Dural Ministry of Justice - Turkey
Aliyev Vugar
Arş. Gör. Seda Kaya Ministry of Justice - Turkey
Prof. Dr. Serap YALÇIN AZARKAN Kırşehir Ahi Evran Üniversitesi, Türkiye
Karakus Ayse
Soylemezoglu Tulin
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | LC GC NORTH AMERICA | ||
| Dergi ISSN | 1527-5949 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2010 |
| Cilt / Sayı / Sayfa | 28 / 7 / 540–543 | DOI | – |
| UAK Araştırma Alanları |
Toksikoloji
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| Özet |
| This study presents a headspace gas chromatography method with flame ionization detection (GC-FID) for the determination of ethanol and methanol content in biological fluids such as blood, urine, and saliva, emphasizing matrix effects onto headspace analytical results. In this context, a simultaneous procedure was established and validated, and it was revealed that headspace GC for methanol and ethanol determination in all routinely available biological fluids is applicable as a reference method and also in routine diagnostics and monitoring. GC was performed with a run time'of 6 min. The method showed linearity in the range of 50-400 mg/dL both for methanol and ethanol ([r. sup. 2]= 0.998 and [r. sup. 2]= 0.999, respectively) in all specimens with a detection and quantification limits less than 1.5 mg/dL and 2 mg/dL, respectively, as well as with good repeatability. Relative standard deviation and percent bias … |
| Anahtar Kelimeler |
