Idarubicin loaded folic acid conjugated magnetic nanoparticles as a targetable drug delivery system for breast cancer
Yazarlar (9)
Ufuk Gündüz
Orta Doğu Teknik Üniversitesi, Türkiye
Orta Doğu Teknik Üniversitesi, Türkiye
Keskin Tugba
Tansık Gulistan
Mutlu Pelin
Prof. Dr. Serap YALÇIN AZARKAN Kırşehir Ahi Evran Üniversitesi, Türkiye
Unsoy Gozde
Prof. Dr. Arzu Yakar Afyon Kocatepe Üniversitesi, Türkiye
Khodadust Rouhollah
Gunduz Gungor
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | BIOMEDICINE & PHARMACOTHERAPY (Q3) | ||
| Dergi ISSN | 0753-3322 Dergi Bilgileri (2014) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2014 |
| Cilt / Sayı / Sayfa | 68 / 6 / 729–736 | DOI | 10.1016/j.biopha.2014.08.013 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S0753332214001073 | ||
| UAK Araştırma Alanları |
Toksikoloji
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| Özet |
| Conventional cancer chemotherapies cannot differentiate between healthy and cancer cells, and lead to severe side effects and systemic toxicity. Another major problem is the drug resistance development before or during the treatment. In the last decades, different kinds of controlled drug delivery systems have been developed to overcome these shortcomings. The studies aim targeted drug delivery to tumor site. Magnetic nanoparticles (MNP) are potentially important in cancer treatment since they can be targeted to tumor site by an externally applied magnetic field. In this study, MNPs were synthesized, covered with biocompatible polyethylene glycol (PEG) and conjugated with folic acid. Then, anti-cancer drug idarubicin was loaded onto the nanoparticles. Shape, size, crystal and chemical structures, and magnetic properties of synthesized nanoparticles were characterized. The characterization of synthesized … |
| Anahtar Kelimeler |
| Idarubicin | Folic acid | Polyethylene glycol (PEG) | Magnetic nanoparticle | Drug delivery | MCF-7 |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 70 |
| Google Scholar | 87 |