Effects of the interleukin 6 IL 6 polymorphism on toxic metal and trace element levels in placental tissues
Yazarlar (6)
Zeliha Kayaaltı
Ankara Üniversitesi, Türkiye
Ankara Üniversitesi, Türkiye
Deniz Tekin Ankara Üniversitesi, Türkiye
Aliyev Vugar
Prof. Dr. Serap YALÇIN AZARKAN Kırşehir Ahi Evran Üniversitesi, Türkiye
Kurtay Gülay
Tülin Söylemezoğlu
Ankara University, Türkiye
Ankara University, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | SCIENCE OF THE TOTAL ENVIRONMENT | ||
| Dergi ISSN | 0048-9697 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 11-2011 |
| Kabul Tarihi | 12-04-2026 | Yayınlanma Tarihi | – |
| Cilt / Sayı / Sayfa | 409 / 23 / 4929–4933 | DOI | 10.1016/j.scitotenv.2011.08.036 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S0048969711009016 | ||
| Özet |
| The placenta is a crucial organ of fetal origin that functions in providing nutrients to the fetus from the mother. During pregnancy, the need for essential micronutrients, such as Fe and Zn, increases due to the requirements of the growing fetus. Maternal Fe deficiency induces an increase in Cu levels and can also affect cytokine levels in the placenta. On the other hand, Cu deficiency, although not as common, can also have destructive effects on the fetus. Interleukin-6 (IL-6) is a pleiotropic cytokine with a wide range of biological activities, including such as immune responses, acute-phase reactions, and inflammation. The placenta produces a significant amount of IL-6 during pregnancy. The effects of the IL-6 −174 G/C single nucleotide polymorphism (SNP) on IL-6 gene transcription and on plasma cytokine levels were assessed in the present study. We investigated the association between the IL-6 −174 G/C … |
| Anahtar Kelimeler |
| Interleukin-6 | Polymorphism | Trace elements | Heavy metals | Placenta |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 15 |
| Web of Science | 6 |