| Yazarlar |
Prof. Dr. Serap YALÇIN AZARKAN
Ahi Evran Üniversitesi, Türkiye |
Khodadust Rouhollah
|
|
Ünsoy Gözde
|
|
Garip Ceren İmmihan
|
|
Mumcuoğlu Didem Zahide
|
|
Ufuk Gündüz
Orta Doğu Teknik Üniversitesi, Türkiye |
| Özet |
| In this study, polyhydroxybutyrate (PHB) coated magnetic nanoparticles were prepared which are targetable to tumor cells in the presence of a magnetic field. The structural properties, functional groups, size distribution, and magnetic properties of the synthesized PHB coated magnetic nanoparticles were characterized by X-ray diffraction, Fourier transform infrared spectrometer, transmission electron microscopy, dynamic light scattering, vibrating sample magnetometry, and thermogravimetric analysis. PHB coated nanoparticles are efficiently internalized by the cancer cells in culture, without cytotoxicity. The results demonstrated that PHB coated iron oxide nanoparticles are suitable for targeted delivery of drugs such as chemotherapeutics, siRNA, miRNA, or antibodies. |
| Anahtar Kelimeler |
| polyhydroxybutyrate, magnetic nanoparticle, anticancer agents, cytotoxicity, genotoxicity |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry |
| Dergi ISSN | 1553-3174 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 09-2015 |
| Doi Numarası | 10.1080/15533174.2013.831448 |
| Makale Linki | http://www.tandfonline.com/doi/abs/10.1080/15533174.2013.831448 |
| Atıf Sayıları | |
| WoS | 10 |
| Google Scholar | 14 |
