Synthesis and characterization of Poly hydroxybutyrate PHB coated magnetic nanoparticles toxicity analyses on different cell lines
Yazarlar (6)
Prof. Dr. Serap YALÇIN AZARKAN
Kırşehir Ahi Evran Üniversitesi, Türkiye
Orta Doğu Teknik Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | SYNTHESIS AND REACTIVITY IN INORGANIC METAL-ORGANIC AND NANO-METAL CHEMISTRY | ||
| Dergi ISSN | 1553-3174 | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2015 |
| Cilt / Sayı / Sayfa | 45 / 5 / 700–708 | DOI | 10.1080/15533174.2013.831448 |
| Makale Linki | http://www.tandfonline.com/doi/abs/10.1080/15533174.2013.831448 | ||
| Özet |
| In this study, polyhydroxybutyrate (PHB) coated magnetic nanoparticles were prepared which are targetable to tumor cells in the presence of a magnetic field. The structural properties, functional groups, size distribution, and magnetic properties of the synthesized PHB coated magnetic nanoparticles were characterized by X-ray diffraction, Fourier transform infrared spectrometer, transmission electron microscopy, dynamic light scattering, vibrating sample magnetometry, and thermogravimetric analysis. PHB coated nanoparticles are efficiently internalized by the cancer cells in culture, without cytotoxicity. The results demonstrated that PHB coated iron oxide nanoparticles are suitable for targeted delivery of drugs such as chemotherapeutics, siRNA, miRNA, or antibodies. |
| Anahtar Kelimeler |
| polyhydroxybutyrate | magnetic nanoparticle | anticancer agents | cytotoxicity | genotoxicity |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 10 |
| Google Scholar | 16 |