Association between XRCC3 Thr241Met polymorphism and laryngeal cancer susceptibility in Turkish population
Yazarlar (9)
Prof. Dr. Serap YALÇIN AZARKAN Kırşehir Ahi Evran Üniversitesi, Türkiye
Yaylacı Atılay
Unsoy Gozde
Saylam Güleser
Akın İstemihan
Gunduz Ufuk
Hakan Korkmaz Ankara Yildirim Beyazit University, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY | ||
| Dergi ISSN | 0937-4477 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2015 |
| Kabul Tarihi | 12-04-2026 | Yayınlanma Tarihi | – |
| Cilt / Sayı / Sayfa | 272 / 12 / 3779–3784 | DOI | 10.1007/s00405-014-3435-2 |
| Makale Linki | http://link.springer.com/10.1007/s00405-014-3435-2 | ||
| Özet |
| DNA repair systems are essential for normal cell function. Genetic alterations in the DNA repair genes such as X-ray repair cross-complementing group 3 (XRCC3), can cause a change in protein activity which results in cancer susceptibility. The aim of this study was to investigate the association of XRCC3 Thr241Met single nucleotide polymorphism (SNP), smoking and alcohol consumption with the risk of laryngeal cancer in Turkish population. The frequencies of Thr241Met SNP were studied in 58 laryngeal cancer cases (SSC) and 67 healthy individuals. Genomic DNA was isolated from peripheral blood samples of both controls and laryngeal cancer cases. Thr241Met SNP was genotyped by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) method. The genotype and allele frequencies of Thr241Met polymorphism were not statistically significant between the laryngeal cancer … |
| Anahtar Kelimeler |
| Laryngeal cancer | SNP | XRCC3 | DNA repair |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 7 |
| Web of Science | 4 |