Half generations magnetic PAMAM dendrimers as an effective system for targeted gemcitabine delivery
Yazarlar (5)
Maryam Parsian Middle East Technical University, Türkiye
Pelin Mutlu Orta Doğu Teknik Üniversitesi, Türkiye
Prof. Dr. Serap YALÇIN AZARKAN Kırşehir Ahi Evran Üniversitesi, Türkiye
Ayşen Tezcaner Orta Doğu Teknik Üniversitesi, Türkiye
Ufuk Gündüz Orta Doğu Teknik Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | INTERNATIONAL JOURNAL OF PHARMACEUTICS | ||
| Dergi ISSN | 0378-5173 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2016 |
| Kabul Tarihi | 12-04-2026 | Yayınlanma Tarihi | – |
| Cilt / Sayı / Sayfa | 515 / 1 / 104–113 | DOI | 10.1016/j.ijpharm.2016.10.015 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S0378517316309498 | ||
| Özet |
| Tumor-specific delivery of anticancer drugs by magnetic nanoparticles will maximize the efficacy of the drug and minimize side effects, and reduce systemic toxicity. The magnetic core of these nanoparticles provides an advantage for selective drug targeting as they can be targeted to the tumor site and accumulated in cancer cells by means of an external magnetic field. Magnetic nanoparticles can be coated with Polyamidoamine (PAMAM) dendrimer and loaded with drugs. However, biomedical applications of PAMAM dendrimers are limited due to their toxicity associated with their multiple cationic charges due to terminal single bondNH2 groups. Modifying the positively charged end groups with negatively charged single bondCOOH groups, is a satisfactory strategy for obtaining less toxic PAMAM dendrimers. Gemcitabine being an analogue of deoxycytidine, is an effective anticancer drug. However, clinical … |
| Anahtar Kelimeler |
| Half generation PAMAM dendrimer | Gemcitabine | Magnetic nanoparticles | Chemotherapy | MCF-7 | SKBR-3 |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 59 |
| Web of Science | 33 |