Loading of Gemcitabine on chitosan magnetic nanoparticles increases the anti cancer efficacy of the drug
Yazarlar (6)
Gözde Ünsoy Middle East Technical University, Türkiye
Pelin Mutlu Orta Doğu Teknik Üniversitesi, Türkiye
Prof. Dr. Serap YALÇIN AZARKAN Kırşehir Ahi Evran Üniversitesi, Türkiye
Ayşen Tezcaner Middle East Technical University, Türkiye
Ufuk Gündüz Orta Doğu Teknik Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | EUROPEAN JOURNAL OF PHARMACOLOGY | ||
| Dergi ISSN | 0014-2999 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2016 |
| Kabul Tarihi | 12-04-2026 | Yayınlanma Tarihi | – |
| Cilt / Sayı / Sayfa | 784 / 0 / 121–128 | DOI | 10.1016/j.ejphar.2016.05.016 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S0014299916303193 | ||
| Özet |
| Targeted delivery of anti-cancer drugs increase the efficacy, while decreasing adverse effects. Among various delivery systems, chitosan coated iron oxide nanoparticles (CsMNPs) gained attention with their biocompatibility, biodegradability, low toxicity and targetability under magnetic field. This study aimed to increase the cellular uptake and efficacy of Gemcitabine.CsMNPs were synthesized by in situ co-precipitation and Gemcitabine was loaded onto the nanoparticles. Nanoparticle characterization was performed by TEM, FTIR, XPS, and zeta potential. Gemcitabine release and stability was analyzed. The cellular uptake was shown. Cytotoxicity of free-Gemcitabine and Gem-CsMNPs were examined on SKBR and MCF-7 breast cancer cells by XTT assay.Gemcitabine loading was optimized as 30 µM by spectrophotometric analyses. Drug release was highest (65%) at pH 4.2, while it was 8% at pH 7.2. This is a … |
| Anahtar Kelimeler |
| Chitosan | Magnetic nanoparticles | Gemcitabine | Targeted drug delivery | Breast cancer |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 128 |
| Web of Science | 89 |