Determınatıon Of The Relatıonshıp Between Doxorubıcın Resıstance And Wnt Sıgnalıng Pathway In Hela And K562 Cell Lınes
Yazarlar (5)
Pelin Mutlu Orta Doğu Teknik Üniversitesi, Türkiye
Prof. Dr. Serap YALÇIN AZARKAN Kırşehir Ahi Evran Üniversitesi, Türkiye
Negar Taghavi Pourianazar Middle East Technical University, Türkiye
Ufuk Gündüz Middle East Technical University, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | EXCLI JOURNAL | ||
| Dergi ISSN | 1611-2156 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2018 |
| Kabul Tarihi | 12-04-2026 | Yayınlanma Tarihi | – |
| Cilt / Sayı / Sayfa | 17 / 0 / 386–398 | DOI | 10.17179/excli2018-1129 |
| Özet |
| Activation of the Wnt signaling in some types of cancer and its relation with chemotherapy resistance is a very interesting issue that has been emphasized in recent years. Although, it is known that increase in the activity of β-catenin is important in blast transformation and drug resistance, the underlying mechanisms are still unclear. In this study, changes in the expression levels of 186 genes that are thought to be important in drug resistance and Wnt signaling pathways were determined by using qPCR method in doxorubicin-sensitive and -resistant HeLa and K562 cell lines. It has been observed that the genes involved in the Wnt signaling pathways are involved in more changes in HeLa/Dox cells (36 genes) than in the K562/Dox cells (17 genes). Genes important for the development of cancer resistance have been found to be significantly different in expression levels of 18 genes in HeLa/Dox cells and 20 genes … |
| Anahtar Kelimeler |
| Wnt signaling pathway | drug resistance | cervical cancer | chronic myelogenous leukemia | gene expression |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 10 |
| Web of Science | 6 |