| Yazarlar (2) |
Rana Köksal
|
Prof. Dr. Serap YALÇIN AZARKAN
Kırşehir Ahi Evran Üniversitesi, Türkiye |
| Özet |
| In this study, we designed PHB-coated iron oxide–based nanoparticle for the delivery of Annona muricata to breast cancer cells and analyzed its therapeutic efficacy in vitro. The structural properties, functional groups, size distribution, and magnetic properties of the synthesized PHB-coated magnetic nanoparticles (MNPs) were characterized in our previous study. The current study visualized protein–ligand interactions by the use of molecular docking. The plant extract was loaded onto PHB-MNPs in different concentrations and the release efficiencies at different pHs were studied under in vitro conditions. The most efficient loading concentration was found about 55% in pH 7.4. The extract-loaded MNPs were stable up to 3 months in neutral pH for mimicking physiological conditions. The release studies were performed with acetate buffer (pH 4.2) that mimics endosomal pH. The plant extract-loaded PHB-MNPs … |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale |
| Dergi Adı | Current Pharmacology Reports |
| Dergi ISSN | 2198-641X Scopus Dergi |
| Dergi Tarandığı Indeksler | CNKIChemical Abstracts Service (CAS)DimensionsEBSCO Discovery ServiceEMBASEGoogle ScholarInstitute of Scientific and Technical Information of ChinaJapanese Science and Technology Agency (JST)MetaNaverOCLC WorldCat Discovery ServiceProQuest-ExLibris PrimoProQuest-ExLibris SummonQinsightReaxysSCImagoSCOPUSTD Net Discovery ServiceUGC-CARE List (India) |
| Makale Dili | İngilizce |
| Basım Tarihi | 06-2020 |
