| Yazarlar (1) |
Prof. Dr. Serap YALÇIN AZARKAN
Kırşehir Ahi Evran Üniversitesi, Türkiye |
| Özet |
| Cancer disease leads to deaths worldwide. Anti-cancer drugs have a high prevalence of side effects and cause multidrug resistance (MDR) that remains a significant barrier to major cancer therapy. To date, chemical and herbal substances have been analyzed for their MDR modulatory activity. However, research on new and safe molecules has been continued to overcome MDR in cancer. The plant compounds can be an effective inhibitor for successful cancer therapy. Recently, computational models have gained importance to discover new inhibitors. In the present study, we aimed to explore the various compounds of Passiflora species as P-gp inhibitor. P-gp protein was docked with the active substrate and inhibitor, respectively, including tamoxifen and verapamil. Besides, 3D structure of P-gp was docked with 11 compounds (luteolin, beta amyrin, beta-sitosterol, chimaphilin, chrysin, edulan I and II, apigenin … |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale |
| Dergi Adı | Current Pharmacology Reports |
| Dergi ISSN | 2198-641X Scopus Dergi |
| Dergi Tarandığı Indeksler | CNKIChemical Abstracts Service (CAS)DimensionsEBSCO Discovery ServiceEMBASEGoogle ScholarInstitute of Scientific and Technical Information of ChinaJapanese Science and Technology Agency (JST)MetaNaverOCLC WorldCat Discovery ServiceProQuest-ExLibris PrimoProQuest-ExLibris SummonQinsightReaxysSCImagoSCOPUSTD Net Discovery ServiceUGC-CARE List (India) |
| Makale Dili | İngilizce |
| Basım Tarihi | 09-2020 |
