Characterization of Gemcitabine Loaded Polyhydroxybutyrate Coated Magnetic Nanoparticles for Targeted Drug Delivery
Yazarlar (4)
Maryam Parsian
Middle East Technical University
Middle East Technical University
Pelin Mutlu Orta Doğu Teknik Üniversitesi, Türkiye
Prof. Dr. Serap YALÇIN AZARKAN Kırşehir Ahi Evran Üniversitesi, Türkiye
Ufuk Gündüz
Middle East Technical University, Türkiye
Middle East Technical University, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | ||
| Dergi ISSN | 1871-5206 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2020 |
| Cilt / Sayı / Sayfa | 20 / 10 / 1233–1240 | DOI | 10.2174/1871520620666200310091026 |
| Özet |
| Background Targeted drug delivery is one of the recent hot topics in cancer therapy. Because of having a targeting potential under the magnetic field and a suitable surface for the attachment of different therapeutic moieties, magnetic nanoparticles are widely studied for their applications in medicine. Objective Gemcitabine loaded polyhydroxybutyrate coated magnetic nanoparticles (Gem-PHB-MNPs) were synthesized and characterized for the treatment of breast cancer by the targeted drug delivery method. Methods The characterization of nanoparticles was confirmed by FTIR, XPS, TEM, and spectrophotometric analyses. The cytotoxicities of drug-free nanoparticles and Gemcitabine loaded nanoparticles were determined with cell proliferation assay using SKBR-3 and MCF-7 breast cancer cell lines. Results The release of Gemcitabine from PHB-MNPs indicated a pH-dependent pattern, which is a desirable … |
| Anahtar Kelimeler |
| Polyhydroxybutyrate | magnetic nanoparticles | gemcitabine | breast cancer | SKBR-3 | MCF-7 | targeting drug delivery |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 24 |
| Web of Science | 15 |