The secondary metabolites produced by Lactobacillus plantarum downregulate BCL-2 and BUFFY genes on breast cancer cell line and model organism Drosophila melanogaster: Molecular docking approach
Yazarlar (3)
Melih Şentürk
Kirsehir Ahi Evran University, Türkiye
Kirsehir Ahi Evran University, Türkiye
Prof. Dr. Fahriye ERCAN Kırşehir Ahi Evran Üniversitesi, Türkiye
Prof. Dr. Serap YALÇIN AZARKAN Kırşehir Ahi Evran Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | CANCER CHEMOTHERAPY AND PHARMACOLOGY | ||
| Dergi ISSN | 0344-5704 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2020 |
| Cilt / Sayı / Sayfa | 85 / 1 / 33–45 | DOI | 10.1007/s00280-019-03978-0 |
| Özet |
| PurposeThe current study was designed to evaluate the toxicity of the secondary metabolites of Lactobacillus plantarum against the human breast cancer cell line (MCF-7) and the Drosophila melanogaster.MethodsIn this study, toxicity analyses of secondary metabolites of Lactobacillus plantarum were analyzed on breast cancer cells, and the Drosophila melanogaster. After application, in the MCF-7 cell line, expression levels of RRAS-2, TP53, BCL-2, APAF-1, CASP-3, FADD, CASP-7, BOK genes; in D. melanogaster; expression levels of RAS64B P53, BUFFY, DARK, DECAY, FADD, DRICE, and DEBCL genes were determined by RT-PCR. In addition, analysis of L. plantarum secondary metabolite was performed by GC–MS method and molecular binding poses of secondary metabolites and human enzymes were investigated in silico.ResultsDrosophila melanogaster being used as a model organism where some … |
| Anahtar Kelimeler |
| Lactobacillus plantarum | Drosophila melanogaster | MCF-7 | Molecular docking | Apoptosis | Gene expression |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 28 |
| Google Scholar | 32 |