| Yazarlar |
Murat Mutlu
Türkiye |
|
Pelin Mutlu
Türkiye |
Prof. Dr. Serap YALÇIN AZARKAN
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Ömer Bayır
Türkiye |
|
Güleser Saylam
Türkiye |
|
Mehmet Hakan Korkmaz
Türkiye |
| Özet |
| Upregulation of the epidermal growth factor receptor (EGFR) gene has shown an important impact on the development of head and neck cancers due to its important regulation role on multiple cell signaling pathways. The aim of this study was to investigate the methylation pattern of the promoter region of the EGFR gene between head and neck squamous cell carcinoma (HNSCC) patients and a control group. Forty-seven unrelated HNSCC patients, clinically diagnosed at the Department of Otorhinolaryngology, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey, and 48 unrelated healthy volunteers from different geographic regions of Turkey, were included in this study. Methylation status of the promoter region of the EGFR gene was detected by methylation-specific-polymerase chain reaction (MS-PCR). The correlation between EGFR gene promoter methylation profiles and clinical characteristics were examined using the chi(2) test. Methylation was observed in 79.0% of HNSCC patients, whereas this ratio was 90.0% in healthy individuals. The results show that promoter region methylation of the EGFR gene was not associated with HNSCC development in the studied Turkish patient group. In addition, the methylation status of the EGFR gene promoter was not found to be related to age, gender or tumor stage. |
| Anahtar Kelimeler |
| Epidermal growth factor receptor (EFGR) gene, epigenetics, head and neck squamous cell carcinoma (HNSCC), methylation, methylation-specific-polymerase chain reaction (MS-PCR) |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Balkan Journal of Medical Genetics |
| Dergi ISSN | 1311-0160 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | Türkçe |
| Basım Tarihi | 01-2020 |
| Cilt No | 23 |
| Doi Numarası | 10.2478/bjmg-2020-0025 |
| Makale Linki | http://dx.doi.org/10.2478/bjmg-2020-0025 |
| Atıf Sayıları |
