Determination of the effect of L. plantarum AB6-25, L. plantarum MK55 and S. boulardii T8-3C microorganisms on colon, cervix, and breast cancer cell lines: Molecular docking, and molecular dynamics study
Yazarlar (3)
Seda Yalçınkaya Suleyman Demirel University, Türkiye
Prof. Dr. Serap YALÇIN AZARKAN Kırşehir Ahi Evran Üniversitesi, Türkiye
Aynur Gül Karahan Çakmakçı Suleyman Demirel University, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | JOURNAL OF MOLECULAR STRUCTURE (Q3) | ||
| Dergi ISSN | 0022-2860 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 08-2022 |
| Kabul Tarihi | 12-04-2026 | Yayınlanma Tarihi | – |
| Cilt / Sayı / Sayfa | 1261 / 0 / 132939–0 | DOI | 10.1016/j.molstruc.2022.132939 |
| Makale Linki | http://dx.doi.org/10.1016/j.molstruc.2022.132939 | ||
| Özet |
| Cancer constitutes an important part of the diseases that are caused all over the world. Due to the side effects of commonly used treatment options such as chemotherapy and radiotherapy, there has been a tendency to seek natural anticancer compounds. In this study, the cytotoxic effects of L. plantarum AB6-25, L. plantarum MK55, and S. boulardii T8-3C probiotic strains on HCT-116, HeLa, and MDA-MB-231 cell lines were determined. The effect of the microorganisms’ cell contents was also evaluated in 3D cancer cell lines. To evaluate the effect of microorganisms on metastasis, we applied to wound healing and invasion assays. At the same time, the cytotoxic effect of microorganisms on cancer cell lines was determined at the gene level using Real-Time qPCR. In addition, the effect of microorganisms on the expression of CASP3 protein in HeLa cells was also evaluated. At the last stage of the study, molecular … |
| Anahtar Kelimeler |
| Cancer | Apoptosis | Probiotics | Molecular docking | Molecular dynamic |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 16 |
| Web of Science | 14 |