img
img
Antiproliferative activity and interaction with proteins of N-cyclohexylacrylamide   
Yazarlar (2)
Prof. Dr. Serap YALÇIN AZARKAN Prof. Dr. Serap YALÇIN AZARKAN
Kırşehir Ahi Evran Üniversitesi, Türkiye
Nevin Çankaya
Uşak Üniversitesi, Türkiye
Devamını Göster
Özet
N-cyclohexylacrylamıde (NCA), the synthesized compound, was evaluated for their cytotoxic activities against HeLa cancer cell line. Also, the current study has been analyzed by the use of molecular docking as protein-ligand interactions play a vital role in drug design. The docking study of NCA was performed with BCL-2, BCL-W, MCl-1, AKT, BRAF, CDK2, VEGFR, EGFR PARP1, CDK6 proteins. The 3D structures of proteins were obtained from the protein data bank and 3D structure of NCA compounds using GAUSSIAN. The in silico molecular docking results indicated that NCA compound can inhibit cancer-related proteins and can play a role as potential lead compounds for developing new drugs for cancer therapy with chemical modification.
Anahtar Kelimeler
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale
Dergi Adı Saudi Journal of Biological Sciences
Dergi ISSN 1319-562X Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q1
Makale Dili Türkçe
Basım Tarihi 11-2022
Cilt No 29
Doi Numarası 10.1016/j.sjbs.2020.04.030
Makale Linki http://dx.doi.org/10.1016/j.sjbs.2020.04.030
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
Google Scholar 10
Antiproliferative activity and interaction with proteins of N-cyclohexylacrylamide

Paylaş