Investigation of the Therapeutic Effects of Palbociclib Conjugated Magnetic Nanoparticles on Different Types of Breast Cancer Cell Lines
Yazarlar (5)
Maryam Parsian Middle East Technical University, Türkiye
Pelin Mutlu Ankara Üniversitesi, Türkiye
Negar Taghavi Pourianazar Istanbul Aydin University, Türkiye
Prof. Dr. Serap YALÇIN AZARKAN Kırşehir Ahi Evran Üniversitesi, Türkiye
Ufuk Gündüz Middle East Technical University, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | CELLULAR AND MOLECULAR BIOENGINEERING (Q3) | ||
| Dergi ISSN | 1865-5025 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 04-2023 |
| Kabul Tarihi | 12-04-2026 | Yayınlanma Tarihi | – |
| Cilt / Sayı / Sayfa | 16 / 2 / 143–157 | DOI | 10.1007/s12195-022-00758-4 |
| Makale Linki | http://dx.doi.org/10.1007/s12195-022-00758-4 | ||
| Özet |
| Introduction Drug targeting and controlled drug release systems in cancer treatment have many advantages over conventional chemotherapy in terms of limiting systemic toxicity, side effects, and overcoming drug resistance. Methods and Results In this paper, fabricating nanoscale delivery system composed of magnetic nanoparticles (MNPs) covered with poly-amidoamine (PAMAM) dendrimers and using its advantages were fully used to help the chemotherapeutic drug, Palbociclib, effectively reach tumors, specifically and stay stable in the circulation longer. In order to determine whether conjugate selectivity can be increased for the specific drug type, we have reported different strategies for loading and conjugation of Palbociclib to different generations of magnetic PAMAM dendrimers. The best method leading to the highest amount of Palbociclib conjugation was chosen, and the characterization of the … |
| Anahtar Kelimeler |
| Palbociclib | Palbociclib conjugated magnetic nanoparticles | Targeted delivery | Breast cancer | PAMAM dendrimer |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 9 |
| Web of Science | 5 |