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Spectroscopic and In Silico Characterization of Irınotecan-Loaded Nanoparticles: In Vitro Evaluation for Breast Cancer Treatment   
Yazarlar (3)
Fatmanur Özçelik
Prof. Dr. Tevfik Raci SERTBAKAN Prof. Dr. Tevfik Raci SERTBAKAN
Türkiye
Prof. Dr. Serap YALÇIN AZARKAN Prof. Dr. Serap YALÇIN AZARKAN
Kırşehir Ahi Evran Üniversitesi, Türkiye
Devamını Göster
Özet
Cancer has always posed a significant threat to human health. Chemotherapy agents used in cancer treatment can also damage normal cells. The area that attracts the most attention today is the transport of chemotherapeutic drugs and the reduction of their side effects by nanotechnological methods. While increasing the stability of drugs or proteins by using nanoparticles with nanotechnology methods, controlled drug release in the target region is also aimed. Our study, it is aimed to determine the effect of iron oxide nanoparticles coated with poly-3-hydroxybutyrate (PHB) loaded with Irinotecan, an anticancer agent, on cancerous cells. In our study, Irinotecan anticancer agent and PHB molecule drawings, molecular electrostatic potential maps, and Mulliken charges of atoms were calculated with the Gaussian 09 program, and theoretical IR spectra were drawn with the Origin85 program. Before the calculation to be …
Anahtar Kelimeler
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale
Dergi Adı Pleiades Publishing Ltd
Dergi ISSN 0036-0244 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q4
Makale Dili Türkçe
Basım Tarihi 12-2023
Cilt No 97
Doi Numarası 10.1134/S0036024423130095
Makale Linki http://dx.doi.org/10.1134/s0036024423130095