Spectroscopic and In Silico Characterization of Irınotecan-Loaded Nanoparticles: In Vitro Evaluation for Breast Cancer Treatment
Yazarlar (3)
Prof. Dr. Tevfik Raci SERTBAKAN
Kırşehir Ahi Evran Üniversitesi, Türkiye
Prof. Dr. Serap YALÇIN AZARKAN
Kırşehir Ahi Evran Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Pleiades Publishing Ltd (Q4) | ||
| Dergi ISSN | 0036-0244 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 12-2023 |
| Cilt / Sayı / Sayfa | 97 / 0 / – | DOI | 10.1134/S0036024423130095 |
| Makale Linki | http://dx.doi.org/10.1134/s0036024423130095 | ||
| Özet |
| Cancer has always posed a significant threat to human health. Chemotherapy agents used in cancer treatment can also damage normal cells. The area that attracts the most attention today is the transport of chemotherapeutic drugs and the reduction of their side effects by nanotechnological methods. While increasing the stability of drugs or proteins by using nanoparticles with nanotechnology methods, controlled drug release in the target region is also aimed. Our study, it is aimed to determine the effect of iron oxide nanoparticles coated with poly-3-hydroxybutyrate (PHB) loaded with Irinotecan, an anticancer agent, on cancerous cells. In our study, Irinotecan anticancer agent and PHB molecule drawings, molecular electrostatic potential maps, and Mulliken charges of atoms were calculated with the Gaussian 09 program, and theoretical IR spectra were drawn with the Origin85 program. Before the calculation to be … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 4 |