| Yazarlar |
Dilek Akyüzlü
Ankara Üniversitesi, Türkiye |
Doç. Dr. Selin ÖZKAN KOTİLOĞLU
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Şafak Yalçın Şahiner
Kütahya Sağlık Bilimleri Üniversitesi, Türkiye |
|
Ece Ağtaş Ertan
Türkiye |
|
İnci İlhan
Ankara Üniversitesi, Türkiye |
| Özet |
| In this case-control study (423 Turkish subjects), the functional pro-dynorphin (PDYN) 68-bp VNTR polymorphism was genotyped in opioid users receiving sublingual buprenorphine/naloxone treatment (SBNT; n = 129, 119 males and 10 females), in opioid users (OUD; n = 99, 90 males and 9 females), in alcohol users (AUD; n = 75, 75 males) and in controls (n = 120, 109 males and 11 females) to determine the effect of this polymorphism on different treatment responses, heroin or alcohol dependence as well as age onset of first use. The PDYN 68-bp alleles were determined based on the number of repeats and genotypes were classified as "short/ short (SS) ", "short-long (SL) " and "long-long (LL) ". The intensity of craving, withdrawal, depression and anxiety were measured by the Substance Craving Scale (SCS), the Clinical Opiate Withdrawal Scale (COWS), the Beck Depression Inventory-II (BDI-II) and Beck Anxiety Inventory (BAI), respectively. Healthy controls (5.5 +/- 5.8) had significantly lower levels of depressive symptoms compared to OUD (25.4 +/- 13.5), AUD (22.5 +/- 11.3) and SBNT (19.29 +/- 12.2) groups. In OUD group, the LL genotype was associated with decreased intensity of anxiety and depressive symptoms than the SS+SL genotype. The BDI-II scores for PDYN VNTR genotypes within the 4 groups were analysed by two-way ANOVA and statistical differences were found for the groups. SBNT group had significantly lower COWS score than OUD group (1.00 versus 3.00). There were statistically significant differences in the median BAI (11 versus 24) and BDI-II scores (17.5 versus 25) between OUD and SBNT groups, supporting the antidepressant and anxiolytic effects of SBNT in persons with OUD. |
| Anahtar Kelimeler |
| Alcohol, Heroin, Buprenorphine, PDYN 68-bp VNTR, Age onset of first use |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | European Journal of Pharmacology |
| Dergi ISSN | 0014-2999 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q1 |
| Makale Dili | İngilizce |
| Basım Tarihi | 03-2022 |
| Cilt No | 921 |
| Sayfalar | 174862 / |
| Doi Numarası | 10.1016/j.ejphar.2022.174862 |
| Makale Linki | http://dx.doi.org/10.1016/j.ejphar.2022.174862 |
| Atıf Sayıları | |
| WoS | 1 |
| Google Scholar | 1 |
