Profile and functional analysis of small RNAs derived from Aspergillus fumigatus infected with double-stranded RNA mycoviruses
Yazarlar (5)
Doç. Dr. Selin ÖZKAN KOTİLOĞLU Kırşehir Ahi Evran Üniversitesi, Türkiye
Irina Mohorianu
University of East Anglia
University of East Anglia
Ping Xu University of East Anglia
Tamas Dalmay
University of East Anglia
University of East Anglia
Robert Ha Coutts
Imperial College London
Imperial College London
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | BMC GENOMICS (Q1) | ||
| Dergi ISSN | 1471-2164 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 05-2017 |
| Cilt / Sayı / Sayfa | 18 / 1 / 416–416 | DOI | 10.1186/s12864-017-3773-8 |
| Makale Linki | http://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-017-3773-8 | ||
| Özet |
| BackgroundMycoviruses are viruses that naturally infect and replicate in fungi. Aspergillus fumigatus, an opportunistic pathogen causing fungal lung diseases in humans and animals, was recently shown to harbour several different types of mycoviruses. A well-characterised defence against virus infection is RNA silencing. The A. fumigatus genome encodes essential components of the RNA silencing machinery, including Dicer, Argonaute and RNA-dependent RNA polymerase (RdRP) homologues. Active silencing of double-stranded (ds)RNA and the generation of small RNAs (sRNAs) has been shown for several mycoviruses and it is anticipated that a similar mechanism will be activated in A. fumigatus isolates infected with mycoviruses.ResultsTo investigate the existence and nature of A. fumigatus sRNAs, sRNA-seq libraries of virus-free and virus-infected isolates were created using Scriptminer adapters and … |
| Anahtar Kelimeler |
| Aspergillus fumigatus | sRNA-seq | miRNA-like sRNA | Differential expression | Double-stranded RNA mycovirus | vsiRNA | Fungal sRNA |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 30 |
| Google Scholar | 40 |