A novel mycovirus from Aspergillus fumigatus contains four unique dsRNAs as its genome and is infectious as dsRNA
Yazarlar (5)
Lakkhana Kanhayuwa
Imperial College London, İngiltere
Imperial College London, İngiltere
Ioly Kottaloızou
Imperial College London, İngiltere
Imperial College London, İngiltere
Doç. Dr. Selin ÖZKAN KOTİLOĞLU Kırşehir Ahi Evran Üniversitesi, Türkiye
A Patrick Gunnıng
University of East Anglia, İngiltere
University of East Anglia, İngiltere
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (Q1) | ||
| Dergi ISSN | 0027-8424 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2015 |
| Cilt / Sayı / Sayfa | 112 / 29 / 9100–9105 | DOI | 10.1073/pnas.1419225112 |
| Makale Linki | http://www.pnas.org/lookup/doi/10.1073/pnas.1419225112 | ||
| Özet |
| We report the discovery and characterization of a double-stranded RNA (dsRNA) mycovirus isolated from the human pathogenic fungus Aspergillus fumigatus, Aspergillus fumigatus tetramycovirus-1 (AfuTmV-1), which reveals several unique features not found previously in positive-strand RNA viruses, including the fact that it represents the first dsRNA (to our knowledge) that is not only infectious as a purified entity but also as a naked dsRNA. The AfuTmV-1 genome consists of four capped dsRNAs, the largest of which encodes an RNA-dependent RNA polymerase (RdRP) containing a unique GDNQ motif normally characteristic of negative-strand RNA viruses. The third largest dsRNA encodes an S-adenosyl methionine–dependent methyltransferase capping enzyme and the smallest dsRNA a P-A-S–rich protein that apparently coats but does not encapsidate the viral genome as visualized by atomic force … |
| Anahtar Kelimeler |
| mycovirus | infectious dsRNA | protoplast transfection | capping enzyme | virus evolution |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 181 |