Detecting the OPRK1 rs963549 and rs997917 Polymorphisms by Novel PCR-RFLP Methods and Determining Their Genotype/Allele Frequencies in a Turkish Population
Yazarlar (1)
Doç. Dr. Selin ÖZKAN KOTİLOĞLU Kırşehir Ahi Evran Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | BIOLOGY BULLETIN (Q4) | ||
| Dergi ISSN | 1062-3590 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2023 |
| Cilt / Sayı / Sayfa | 50 / 5 / 801–807 | DOI | 10.1134/S1062359022603019 |
| Makale Linki | http://dx.doi.org/10.1134/s1062359022603019 | ||
| Özet |
| Opioid receptor kappa (KOR) is one of three endogenous opioid receptors which has critical roles in rewarding systems by promoting anti-reward effects and causes dysphoria and relapse. KOR is encoded by the OPRK1 gene and the polymorphisms of OPRK1 gene have been reported to be associated with various diseases. OPRK1 rs963549 and rs997917 are two polymorphisms of the OPRK1 gene. They are shown to have potential to affect addiction and alter the response to pharmacotherapy leading to individual differences, therefore they are accepted as marker polymorphisms. Hence, in the current study, it is aimed to develop PCR-RFLP assays to genotype OPRK1 rs963549 and rs997917 polymorphisms. The PCR-RFLP methods were developed for the detection of OPRK1 rs963549 and rs997917 polymorphisms and were tested in 100 healthy Turkish controls. Allele frequencies of rs963549 in the … |
| Anahtar Kelimeler |
| OPRK1 gene | polymorphism | PCR-RFLP | rs963549 | rs997917 | optimization |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |