Effect of PDYN and OPRK1 polymorphisms on the risk of alcohol use disorder and the intensity of depressive symptoms
Yazarlar (5)
Doç. Dr. Selin ÖZKAN KOTİLOĞLU Kırşehir Ahi Evran Üniversitesi, Türkiye
Prof. Dr. Dilek Akyüzlü Ankara Üniversitesi, Türkiye
Rabia Yurdakul Ankara University
Mukaddes Asena Yıldırım Ankara University
Prof. Dr. İnci İlhan Ankara Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | ALCOHOL AND ALCOHOLISM (Q3) | ||
| Dergi ISSN | 0735-0414 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 07-2023 |
| Cilt / Sayı / Sayfa | 58 / 4 / 404–414 | DOI | 10.1093/alcalc/agad036 |
| Makale Linki | http://dx.doi.org/10.1093/alcalc/agad036 | ||
| Özet |
| Aims: The dynorphin (DYN)/Kappa Opioid Receptor (KOR) system has been suggested to be involved in both negative affective states and the action of alcohol. The present study was undertaken to explore whether the DYN/KOR system genes, PDYN and OPRK1, influence on individual differences in the intensity of depressive symptoms at admission as well as the risk of alcohol use disorder (AUD) risk in a sample of 101 individuals with AUD and 100 controls. Methods: PDYN (rs2281285, rs2225749 and rs910080) and OPRK1 (rs6473797, rs963549 and rs997917) polymorphisms were analyzed by PCR-RFLP. The intensity of depressive and anxiety symptoms and craving were measured by the Beck Depression Inventory-II (BDI-II), Beck Anxiety Inventory (BAI), and Penn Alcohol Craving Scale, respectively. Results: A significant association between the risk of AUD and OPRK1 rs6473797 (P < 0.05) at the … |
| Anahtar Kelimeler |
| alcohol use disorder | kappa-opioid receptor | individual difference | OPRK1 rs6473797 | OPRK1 rs963549 |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 6 |
| Google Scholar | 10 |