Association of OPRK1 rs963549 and rs997917 polymorphisms with opioid use disorder and the related phenotypes
Yazarlar (4)
Doç. Dr. Selin ÖZKAN KOTİLOĞLU Kırşehir Ahi Evran Üniversitesi, Türkiye
Dilek Akyüzlü Ankara Üniversitesi, Türkiye
Şafak Yalçın Şahiner Ankara Üniversitesi, Türkiye
Nagihan Ayaz
City Hospital Ankara, Türkiye
City Hospital Ankara, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | PHARMACOGENOMICS (Q3) | ||
| Dergi ISSN | 1462-2416 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2023 |
| Cilt / Sayı / Sayfa | 24 / 6 / 325–334 | DOI | 10.2217/pgs-2023-0037 |
| Makale Linki | http://dx.doi.org/10.2217/pgs-2023-0037 | ||
| Özet |
| Aim: To evaluate the association between OPRK1 rs963549 and rs997917 and opioid use disorder (OUD) and related phenotypes.Methods: A sample of 208 individuals with (n = 100) and without (n = 108) OUD were enrolled. OPRK1 rs963549 and rs997917 were analyzed by PCR-RFLP. Craving, opioid withdrawal and the intensity of depressive and anxiety symptoms were measured by the appropriate scales.Results: OPRK1 rs963549 variation showed a trend of association with decreased opioid withdrawal. No significant associations were found between OPRK1 rs963549 and rs997917 polymorphisms and craving, depression or anxiety symptoms. Neither single OPRK1 SNPs nor OPRK1 haplotypes were associated with OUD.Conclusion: Our results could be useful for treatment failures of individuals who experience greater opioid withdrawal due to their OPRK1 rs963549 genotypes. |
| Anahtar Kelimeler |
| individual differences | opioid use disorder | opioid withdrawal | OPRK1 gene | kappa-opioid receptor |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 2 |
| Google Scholar | 2 |