Sublingual buprenorphine/naloxone treatment is not affected by OPRM1 A118G and BDNF Va66Met polymorphisms, but alters the plasma beta-endorphin and BDNF levels in individuals with opioid use disorder
Yazarlar (6)
Prof. Dr. Dilek Akyüzlü Ankara Üniversitesi, Türkiye
Doç. Dr. Selin ÖZKAN KOTİLOĞLU Kırşehir Ahi Evran Üniversitesi, Türkiye
Prof. Dr. Ceylan Bal Ankara Yıldırım Beyazıt Üniversitesi, Türkiye
Gamze Avcıoğlu
Ankara Yildirim Beyazit University, Türkiye
Ankara Yildirim Beyazit University, Türkiye
Dr. Öğr. Üyesi Şafak Yalçın Şahiner Kütahya Sağlık Bilimleri Üniversitesi, Türkiye
İsmail Volkan Şahiner
Kütahya Sağlık Bilimleri Üniversitesi, Türkiye
Kütahya Sağlık Bilimleri Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (Q1) | ||
| Dergi ISSN | 1382-6689 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2022 |
| Cilt / Sayı / Sayfa | 95 / 0 / 103979–0 | DOI | 10.1016/j.etap.2022.103979 |
| Makale Linki | http://dx.doi.org/10.1016/j.etap.2022.103979 | ||
| Özet |
| The study aimed to examine the genetic contribution to buprenorphine (BUP) treatment in individuals with opioid use disorder (OUD), with a specific focus on BDNF and OPRM1 genes. A total of 113 controls and 111 OUD patients receiving sublingual BUP/naloxone were enrolled. OPRM1 A118G and BDNF Val66Met polymorphisms were investigated by PCR-FRLP. Plasma BDNF and beta-endorphin levels were assessed by ELISA kits in both groups. Blood BUP levels were measured by LC-MS/MS and normalized with daily BUP dose (BUP/D). OPRM1 A118G and BDNF Val66Met polymorphisms didn’t have an effect on plasma beta-endorphin and BDNF levels in OUD patients, respectively. Interestingly, OUD patients had significantly higher plasma BDNF and lower beta-endorphin levels compared to the controls (p < 0.001). A negative and significant correlation between plasma BUP/D and BDNF levels was … |
| Anahtar Kelimeler |
| Beta-endorphin | BDNF | Buprenorphine | Pharmacogenetics |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 2 |
| Google Scholar | 5 |