| Yazarlar |
Dilek Akyüzlü
Ankara Üniversitesi, Türkiye |
Doç. Dr. Selin ÖZKAN KOTİLOĞLU
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Ceylan Bal
Ankara Yıldırım Beyazıt Üniversitesi, Türkiye |
|
Gamze Avcıoğlu
Türkiye |
|
Şafak Yalçın Şahiner
Kütahya Sağlık Bilimleri Üniversitesi, Türkiye |
|
İsmail Volkan Şahiner
Kütahya Sağlık Bilimleri Üniversitesi, Türkiye |
| Özet |
| The study aimed to examine the genetic contribution to buprenorphine (BUP) treatment in individuals with opioid use disorder (OUD), with a specific focus on BDNF and OPRM1 genes. A total of 113 controls and 111 OUD patients receiving sublingual BUP/naloxone were enrolled. OPRM1 A118G and BDNF Val66Met polymorphisms were investigated by PCR-FRLP. Plasma BDNF and beta-endorphin levels were assessed by ELISA kits in both groups. Blood BUP levels were measured by LC-MS/MS and normalized with daily BUP dose (BUP/D). OPRM1 A118G and BDNF Val66Met polymorphisms didn't have an effect on plasma beta-endorphin and BDNF levels in OUD patients, respectively. Interestingly, OUD patients had significantly higher plasma BDNF and lower beta-endorphin levels compared to the controls (p < 0.001). A negative and significant correlation between plasma BUP/D and BDNF levels was found. Age onset of first use was associated with OPRM1 A118G polymorphism. The findings indicated that sublingual BUP/naloxone may increase plasma BDNF levels, but may decrease beta-endorphin levels in individuals with OUD. Plasma BDNF level seemed to be decreased in a BUP/D concentration-dependent manner. |
| Anahtar Kelimeler |
| Beta-endorphin, BDNF, Buprenorphine, Pharmacogenetics |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Environmental Toxicology and Pharmacology |
| Dergi ISSN | 1382-6689 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q1 |
| Makale Dili | İngilizce |
| Basım Tarihi | 10-2022 |
| Cilt No | 95 |
| Sayfalar | 103979 / |
| Doi Numarası | 10.1016/j.etap.2022.103979 |
| Makale Linki | http://dx.doi.org/10.1016/j.etap.2022.103979 |
| Atıf Sayıları | |
| WoS | 1 |
| Google Scholar | 3 |
