| Yazarlar |
Dilek Akyüzlü
Ankara Üniversitesi, Türkiye |
Doç. Dr. Selin ÖZKAN KOTİLOĞLU
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Ceylan Bal
Ankara Yıldırım Beyazıt Üniversitesi, Türkiye |
|
Şafak Yalçın Şahiner
Kütahya Sağlık Bilimleri Üniversitesi, Türkiye |
|
Gamze Avcıoğlu
Türkiye |
|
Mustafa Danışman
|
| Özet |
| This study aimed to determine the effects of UGT2B7 rs7662029 and rs7439366 polymorphisms on plasma buprenorphine (BUP) concentration and different treatment responses in a sample of 109 patients with opioid use disorder (OUD) treated with sublingual BUP/naloxone. Polymorphisms were analysed by PCR-RFLP. Plasma concentrations of BUP and its metabolite norbuprenorphine were detected by LC-MS/MS. Craving, withdrawal, depression and anxiety were measured by appropriate scales. OUD patients with rs7439366 CC or rs7662029 GG genotypes had significantly lower dose-normalized (BUP/D) and dose/kg-normalized BUP (BUP/D.kg(-1)) levels than those who were CT or AA carriers. Significant associations between UGT2B7 rs7662029 and increased craving (p = 0.037) and withdrawal symptoms (p = 0.029) were detected. Our findings were pointing to an important role of UGT2B7 in the metabolism of sublingual BUP/naloxone in the heroin addicts for the first time. A novel PCR-RFLP assay was developed for the determination of UGT2B7 rs7662029 polymorphism, based on utilizing novel restriction enzyme. |
| Anahtar Kelimeler |
| UGT2B7 variation, Heroin addiction, Buprenorphine, PCR-RFLP |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Environmental Toxicology and Pharmacology |
| Dergi ISSN | 1382-6689 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q1 |
| Makale Dili | İngilizce |
| Basım Tarihi | 08-2022 |
| Cilt No | 94 |
| Sayı | 6 |
| Sayfalar | 103902 / |
| Doi Numarası | 10.1016/j.etap.2022.103902 |
| Makale Linki | http://dx.doi.org/10.1016/j.etap.2022.103902 |
| Atıf Sayıları | |
| WoS | 4 |
| Google Scholar | 6 |
