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Prophylaxis of the Occurrence of Hyperbilirubinemia in Relation to Maternal Oxytocin Infusion with Steroid Treatment       
Yazarlar
Özkan Aydın Leylek
Ayça Ergür
Ufuk Üniversitesi, Türkiye
Feyza Şenocak
Mehmet Şencan
Sivas Cumhuriyet Üniversitesi, Türkiye
Sevtap Bakır
Sivas Cumhuriyet Üniversitesi, Türkiye
Himmet Özdemir
 Selda SONGUR DAĞLI Selda SONGUR DAĞLI
Kırşehir Ahi Evran Üniversitesi, Türkiye
Özet
This study was carried out to investigate the steroid prevention on the occurrence and the severity of red blood cell destruction by the effect of oxytocin usage for labor induction. Venous cord blood was collected from the pregnancies who had oxytocin-induced or augmented labors (20), oxytocin-infused deliveries with steroid use (20), deliveries without oxytocin use (20) and cesarean sections (20). Evaluation of the data showed significant increase in serum bilirubin level: serum lactic dehydrogenase activity, erythrocyte fragility and reticulocyte count (p < 0.0083), and a significant decrease in hemoglobulin concentration, packed red cell volume fraction (p < 0.01) in groups with labor induction or augmentation with oxytocin in comoparison to deliveries with oxytocin plus steroid use and the two other methods of delivery. Moreover, with regard to the above data, no significant difference was observed between the deliveries other than oxytocin-only use. Mean corpuscular volume in the oxytocin group was apparently (not significant) higher than the steroid group. The results of this study suggest that the use of 16 mg dexamethasone 21-phosphate at the beginning of the induction or augmentation of labor with oxytocin, followed by an additional 4-mg dose 4 h later intravenously, is advantageous for the prevention of erythrocyte destruction.
Anahtar Kelimeler
oxytocin | hemolysis | hyperbilirubinemia | steroid | membrane stabilization
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı GYNECOLOGIC AND OBSTETRIC INVESTIGATION
Dergi ISSN 0378-7346
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce
Basım Tarihi 01-1998
Cilt No 46
Sayı 3
Sayfalar 164 / 168
Doi Numarası 10.1159/000010025
Makale Linki https://www.karger.com/Article/FullText/10025