Supercritical Carbon Dioxide-Assisted Decellularization of Aorta and Cornea
Yazarlar (4)
Dr. Öğr. Üyesi Selcan GÜLER
Kırşehir Ahi Evran Üniversitesi, Türkiye
Bahar Aslan
Hacettepe Üniversitesi, Türkiye
Pezhman Hosseinian
Hacettepe Üniversitesi, Türkiye
Halil Murat Aydın
Hacettepe Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Tissue Engineering Part C Methods | ||
| Dergi ISSN | 1937-3384 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2017 |
| Cilt / Sayı / Sayfa | 23 / 9 / 540–547 | DOI | 10.1089/ten.tec.2017.0090 |
| Makale Linki | http://online.liebertpub.com/doi/10.1089/ten.tec.2017.0090 | ||
| Özet |
| Tissue engineering approaches utilize both natural and synthetic materials in the repair and regeneration processes. A naturally sourced material for this purpose is required to be free from any antigenic matter such as cells or cellular components. Decellularization of tissues may be achieved through chemical or physical removal agents. Supercritical carbon dioxide (sc-CO2) has been used on the purpose of removing bioburden from tissues and offers an alternative to the traditionally used treatment methods. In addition to many advantages it offers with regard to the successful decellularization of tissues, it is known to have a sterilization effect. This study provides an insight into sc-CO2-assisted decellularization trials of corneal and aortic tissues. Results showed that high pressure of the fluid bursts the cells during the treatment and rapid depressurization was found to be effective in the removal of the cells from the tissues. sc-CO2 decellularization offers significantly reduced treatment times, complete decellularization, and preserved extracellular matrix structure. |
| Anahtar Kelimeler |
| aorta | cornea | decellularization | supercritical carbon dioxide | tissue engineering |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 75 |
| SCOPUS | 86 |
| Google Scholar | 121 |
| ResearchGate | 87 |