| Yazarlar (4) |
Didem Aksoy Körpe
Hacettepe Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Selcan GÜLER
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Halil Murat Aydın
Hacettepe Üniversitesi, Türkiye |
|
Memed Duman
Hacettepe Üniversitesi, Türkiye |
| Özet |
| In this paper, gelatin methacrylate hydrogel scaffold, functionalized with growth factors loaded alginate-chitosan core-shell nanoparticles, were developed to enhance chondrogenic differentiation of adipose-derived mesenchymal stem cells. With the chosen preparation conditions, the encapsulation efficiency of transforming growth factorβ-1 (TGFβ-1) and insulin-like growth factor-1 (IGF-1) was calculated at 93.34% and 91.92%, respectively. The assay groups which contain loaded nanoparticles in hydrogels exhibited the highest DNA and glycosaminoglycan contents with 2.93 and 573.60 µg/sample, respectively. Moreover, in the same group, it was observed that the amount of collagen also increased by 3.6-fold. Thus, the functionalized scaffold is promising construct for tissue engineering applications. |
| Anahtar Kelimeler |
| alginate-chitosan | chondrogenesis | core-shell nanoparticles | gelatin methacrylate | tissue engineering |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS |
| Dergi ISSN | 0091-4037 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI |
| Dergi Grubu | Q4 |
| Makale Dili | Türkçe |
| Basım Tarihi | 01-2021 |
| Cilt No | 72 |
| Sayı | 5 |
| Sayfalar | 11 / 365 |
| Doi Numarası | 10.1080/00914037.2021.2014484 |
| Atıf Sayıları | |
| SCOPUS | 1 |
| Google Scholar | 1 |
