| Yazarlar (8) |
Baris Ciplak
Malatya Training And Research Hospital, Türkiye |
|
Eyup Gokhan Turmus
Hasan Çalık State Hospital, Türkiye |
Doç. Dr. Özlem KARA
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Gulcin Daglioglu
Çukurova Üniversitesi Tip Fakültesi, Türkiye |
|
Mehmet Murat Altindag
Malatya Training And Research Hospital, Türkiye |
|
Yavuz Simsek
Biruni Üniversitesi, Türkiye |
Prof. Dr. Yusuf Kenan DAĞLIOĞLU
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Mustafa Kara
Kırşehir Ahi Evran Üniversitesi, Türkiye |
| Özet |
| OBJECTIVE: The objective of this study was to investigate the protectiveness of resveratrol on cisplatin-induced damage to the ovary using experimental models. METHODS: A total of 30 female Wistar-Albino rats constituted the research material. The rats were categorized into three groups: Group 1 was administered one milliliter of 0.9% NaCl solution, Group 2 was administered 7.5 mg/kg cisplatin, and Group 3 was administered 7.5 mg/kg cisplatin and 10 mg/kg resveratrol. Ovaries were extirpated in all groups and subjected to biochemical and histopathological tests. Cisplatin-induced damage to ovarian tissue was graded and scored as the total histopathological findings score. The ovarian function was assessed using immunohistochemical staining for c-kit expression. Rats’ malondialdehyde, catalase, and superoxide dismutase levels were determined. RESULTS: The histopathological finding score was significantly higher in Group 2 than in other groups (p<0.05). The superoxide dismutase and catalase levels were significantly higher in Group 3 than in Group 2 (p<0.001 for both cases). The malondialdehyde level was significantly higher in Group 2 than in Group 3 (p<0.001). CONCLUSION: The study findings demonstrated that resveratrol reduced ovarian injury and enhanced biochemical parameters following cisplatin-induced ovary damage in experimental models. |
| Anahtar Kelimeler |
| Cisplatin | Ovary | Rat | Resveratrol |
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Revista Da Associacao Medica Brasileira |
| Dergi ISSN | 0104-4230 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 08-2023 |
| Cilt No | 69 |
| Sayı | 8 |
| DOI Numarası | 10.1590/1806-9282.20230314 |
| Makale Linki | https://www.scielo.br/j/ramb/a/QPqsqXjBYMKLnZSzxFmmHJs/?format=pdf&lang=en |
| Atıf Sayıları | |
| WoS | 3 |
| SCOPUS | 3 |
| Google Scholar | 4 |
