| Yazarlar (1) |
Doç. Dr. Özlem KARA
Kırşehir Ahi Evran Üniversitesi, Türkiye |
| Özet |
| Background and Objective Although cyclophosphamide is a potent antineoplastic drug its’ toxic effects such as damage to the liver, kidney and ovary diminished its widespread utilization. This trial was designed to assess the effect of coenzyme Q10 on cyclophosphamide-induced toxicity in rat liver. Materials and Methods The rats were divided into 3 groups: In group 1 (control group)(n= 10), nothing was done, group 2 (cyclophosphamide group)(n= 10), 30 mg kgG1 intraperitoneal cyclophosphamide was administered for 7 days and group 3 (cyclophosphamide+ coenzyme Q10 group)(n= 10), 30 mg kgG1 cyclophosphamide and 10 mg kgG1 coenzyme Q10 were given for 7 days via intraperitoneal route. Biochemical measurements (SOD and CAT activity and MDA level) were performed. The liver of the rats was surgically extirpated in all groups. Histopathological damage in the liver was evaluated. Results The hepatocyte damage markers such as inflammation, hemorrhage, necrosis, edema, parenchymal damage and hepatocyte damage were more common in the cyclophosphamide group than cyclophosphamide+ coenzyme Q10 group (p< 0.05). The activities of SOD and CAT were lower and levels of MDA were higher in the cyclophosphamide group than in the cyclophosphamide+ coenzyme Q10 group (p< 0.05). Conclusion Coenzyme Q10 was found to be efficient in preserving the liver tissue from cyclophosphamide-induced toxic effects. |
| Anahtar Kelimeler |
| Coenzyme Q10 | cyclophosphamide | liver | rat | toxicity | Bcl-2 | immunohistochemistry |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | International Journal of Pharmacology |
| Dergi ISSN | 1811-7775 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 10-2023 |
| Cilt No | 19 |
| Sayı | 4 |
| Sayfalar | 537 / 541 |
| Doi Numarası | 10.3923/ijp.2023.537.541 |
| Makale Linki | https://scialert.net/fulltext/fulltextpdf.php?pdf=ansinet/ijp/2023/537-541.pdf |
| Atıf Sayıları |
