In vitro and in vivo evaluation of doxycycline chondroitin sulfate PCL microspheres for intraarticular treatment of osteoarthritis
Yazarlar (7)
Dr. Öğr. Üyesi Özlem AYDIN Kırşehir Ahi Evran Üniversitesi, Türkiye
Feza Korkusuz Hacettepe Üniversitesi, Türkiye
Petek Korkusuz Hacettepe Üniversitesi, Türkiye
Aysen Tezcaner Middle East Technical University (Metu), Türkiye
Elif Bilgic
Hacettepe Üniversitesi, Türkiye
Hacettepe Üniversitesi, Türkiye
Volkan Yaprakci
Afyon Kocatepe Üniversitesi, Türkiye
Afyon Kocatepe Üniversitesi, Türkiye
Dilek Keskin Middle East Technical University (Metu), Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Biomedical Materials Research Part B Applied Biomaterials | ||
| Dergi ISSN | 1552-4973 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2015 |
| Cilt / Sayı / Sayfa | 103 / 6 / 1238–1248 | DOI | 10.1002/jbm.b.33303 |
| Makale Linki | http://doi.wiley.com/10.1002/jbm.b.33303 | ||
| Özet |
| Osteoarthritis (OA) is a degenerative joint disease, which has no complete treatment with medication yet. Intraarticular hyaluronan (HA) injection can decrease pain and modify the natural course of OA. This study was designed to provide long term delivery of an MMP (matrix‐metalloproteinase) inhibitor agent‐doxycycline, together with matrix regenerative agent‐chondroitin sulfate for treating OA which progress with matrix degenerations. Doxycycline (D) and doxycycline‐chondroitin sulfate (D‐CS) loaded poly‐ɛ‐caprolactone (PCL) microspheres (MS) were prepared as intraarticular delivery systems. Bio‐effectiveness of developed microspheres was first evaluated with three‐dimensional in vitro model of OA where both MS showed significant reduction in MMP‐13 levels compared to untreated OA‐chondrocytes at 15 and 24 days. Significant decrease was observed in GAG release into the media for both D MS … |
| Anahtar Kelimeler |
| articular cartilage | chondroitin sulfate | drug delivery/release | matrix metalloproteinase | microspheres |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 24 |
| Scopus | 6 |
| Web of Science | 16 |