Study on physiochemical structure and in vitro release behaviors of doxycycline loaded PCL microspheres
Yazarlar (4)
Dr. Öğr. Üyesi Özlem AYDIN Kırşehir Ahi Evran Üniversitesi, Türkiye
Baran Aydın Middle East Technical University (Metu), Türkiye
Ayşen Tezcaner Middle East Technical University (Metu), Türkiye
Dilek Keskin Middle East Technical University (Metu), Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Applied Polymer Science | ||
| Dergi ISSN | 0021-8995 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2015 |
| Cilt / Sayı / Sayfa | 132 / 14 / – | DOI | 10.1002/app.41768 |
| Özet |
| This study aimed to develop drug delivery system of doxycycline‐loaded polycaprolactone (PCL) microspheres. The investigated microsphere formulation can be considered for local application in bone infections and degenerative joint diseases, which generally require long‐term treatments via systemic drugs. PCL‐14 kDa and 65 kDa were used in microsphere preparation. Before release, the microspheres were characterized by scanning electron microscopy, differential scanning calorimetry, and X‐ray photoelectron spectroscopy. The mean particle size of microspheres was in the range of 74–122 µm and their drug loadings ranged between 10 and 30%. In vitro release profiles were described using the Higuchi and the Korsmeyer–Peppas equations. Diffusion model was applied to experimental data for estimating diffusion coefficients of microspheres; calculated as between 4.5 × 10−10 and 9.5 × 10−10 cm2/s … |
| Anahtar Kelimeler |
| Biodegradable | Drug delivery systems | Kinetics | Properties and characterization | Theory and modeling |
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| Atıf Sayıları | |
| Google Scholar | 24 |
| Scopus | 6 |
| Web of Science | 20 |