| Yazarlar |
Dr. Öğr. Üyesi Özlem AYDIN
Ahi Evran Üniversitesi, Türkiye |
Baran Aydın
Adana Bilim ve Teknoloji Üniversitesi, Türkiye |
|
Ayşen Tezcaner
Orta Doğu Teknik Üniversitesi, Türkiye |
|
Dilek Keskin
Orta Doğu Teknik Üniversitesi, Türkiye |
| Özet |
| This study aimed to develop drug delivery system of doxycycline-loaded polycaprolactone (PCL) microspheres. The investigated microsphere formulation can be considered for local application in bone infections and degenerative joint diseases, which generally require long-term treatments via systemic drugs. PCL-14 kDa and 65 kDa were used in microsphere preparation. Before release, the microspheres were characterized by scanning electron microscopy, differential scanning calorimetry, and X-ray photoelectron spectroscopy. The mean particle size of microspheres was in the range of 74-122 mu m and their drug loadings ranged between 10 and 30%. In vitro release profiles were described using the Higuchi and the Korsmeyer-Peppas equations. Diffusion model was applied to experimental data for estimating diffusion coefficients of microspheres; calculated as between 4.5 x 10(-10) and 9.5 x 10(-10) cm(2)/s. Although long-term release from microspheres of PCL-14 kDa obeyed diffusion model, PCL-65 kDa microspheres showed this tendency only for some period. Modeling studies showed that the drug release mechanism was mainly dependent on loading and molecular weight differences. Release behavior of PCL-65 kDa microspheres, however, might be better represented by derivation of a different equation to model for the total release period. (c) 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41768 |
| Anahtar Kelimeler |
| biodegradable, drug delivery systems, kinetics, properties and characterization, theory and modeling |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Journal of Applied Polymer Science |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 04-2015 |
| Cilt No | 132 |
| Sayı | 14 |
| Doi Numarası | 10.1002/APP.41768 |
| Atıf Sayıları | |
| WoS | 15 |
