INVESTIGATION OF THE STABILIZATION OF CAMPTOTHECIN ANTICANCER DRUG VIA PSA PEG POLYMERIC PARTICLES
Yazarlar (5)
Dr. Öğr. Üyesi Nuriye Tuna SUBAŞI
Kırşehir Ahi Evran Üniversitesi, Türkiye
Kocaeli Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (Diğer hakemli ulusal dergilerde yayınlanan tam makale) | ||
| Dergi Adı | Anadolu Üniversitesi Bilim ve Teknoloji Dergisi A- Uygulamalı Bilimler ve Mühendislik | ||
| Dergi Tarandığı Indeksler | EBSCO | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2016 |
| Özet |
| Syntheses of biodegradable PSA:PEG copolymers for the formation of nano and micro carriers were performed. Camptothecin (CPT) was selected as anti-cancer drug. CPT can easily hydrolyze at physiological conditions (pH=7.4). This causes the loss of its activity, and it turns into inactive toxic carboxylate form from active lactone state. To keep anti cancer drug in the lactone form, it was efficiently loaded into PSA:PEG nanoparticles and microparticles, and the stability of CPT in the carriers was fully examined with HPLC. It was found that the drug was highly stable and in active form in the prepared nano and microcarriers (>95 %). Particles were imaged with confocal, SEM, and optic microscopes. |
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