| Yazarlar (5) |
Nurhan Gumrukcuoglu
Karadeniz Technical University, Türkiye |
|
Mevlut Serdar
Karadeniz Technical University, Türkiye |
|
Elif Çelik
Karadeniz Technical University, Türkiye |
Prof. Dr. Ali SEVİM
Karadeniz Technical University, Türkiye |
|
Neslihan Demirbaş
Karadeniz Technical University, Türkiye |
| Özet |
| A series of acylhydrazones (2a-f ) were synthesized by the condensation of iminoester hydrochlorides (1a-f ) with acyl hydrazines. 2,5-Dialkyl 1,3,4-oxadiazoles (3a,c,e) were obtained in the same reaction media. The treatment of acylhydrazones with hydrazine hydrate afforded 4-amino-3,5-dialkyl-1,2,4- triazoles (4a-c). The acetylation of 4-amino-3,5-dialkyl-1,2,4-triazoles produced N-[3,5-dialkyl-4H- 1,2,4-triazol-4-yl] acetamides (5-7). The treatment of compounds 4a and 4c with various aromatic aldehydes resulted in the formation of 4-arylidenamino-3,5-dialkyl-1,2,4-triazoles (8a,d, e, and 10a-e). Sodium borohydride reduction of 4-arylidenamino derivatives afforded 4-alkylamino-3,5-dialkyl-1,2,4-triazoles (9a,d, e, and 11a-e). Compounds 4b, 4c, 7, 8d, and 11c showed good antifungal activity only against yeast-like fungi, while compounds 3e, 6, 8e, and 9e showed antimicrobial activity against bacteria and yeast-like fungi. |
| Anahtar Kelimeler |
| 1,2,4-triazole | 1,3,4-oxadiazole | Acetylation | Acyl hydrazone | Antimicrobial activity | Reduction | Schiff Base |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Turkish Journal of Chemistry |
| Dergi ISSN | 1300-0527 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2007 |
| Cilt No | 31 |
| Sayı | 3 |
| Sayfalar | 335 / 348 |
| Makale Linki | http://journals.tubitak.gov.tr/chem/issues/kim-07-31-3/kim-31-3-10-0602-22.pdf |
