| Yazarlar |
Ahmet Gürer
|
|
Mehmet Ozdogan
|
|
İsmail Gömceli
|
|
Ata Türker Arıkök
|
|
Hakan Kulaçoğlu
|
|
Özalp Dündar Karabay
|
Prof. Dr. Nuraydın ÖZLEM
Ahi Evran Üniversitesi, Türkiye |
| Özet |
| Background: Oxygen-derived free radicals play an important role in ischemia-reperfusion injury (IR). Hyperbaric oxygenation (HO) decreases free radical production. The aim of this study was to determine the effect of HO treatment on renal ischemia-reperfusion injury in rats. Methods: Rats were divided into four groups. All groups underwent right nephrectomy. Group I served as the control group; group II had left renal ischemia-reperfusion; group III was pretreated with HO; and group IV, ischemia-reperfusion and HO pretreatment. Tissue malondialdehyde (MDA) and glutathione (GSH) levels were measured, and histopathologic damage scored. Results: HO pretreatment significantly decreased tissue MDA levels and histopathologic scores among rats with IR. There was an increased GSH in HO-pretreated rats with IR; however, the difference was not significant. Conclusion: HO prior to ischemia displayed a beneficial effect on renal IR by reducing oxygen radical peroxidation of lipid membranes. © 2006 Elsevier Inc. All rights reserved. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | transplantation proceedings |
| Dergi ISSN | 0041-1345 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2006 |
| Cilt No | 38 |
| Sayı | 10 |
| Sayfalar | 3337 / 3340 |
| Doi Numarası | 10.1016/j.transproceed.2006.10.184 |
| Atıf Sayıları | |
| SCOPUS | 21 |
| Google Scholar | 31 |
