| Yazarlar |
Alyar Saliha
|
Neslihan ÖZBEK
Ahi Evran Üniversitesi, Türkiye |
|
Kuzukıran Kübra
|
|
Nurcan Karacan
Gazi Üniversitesi, Türkiye |
| Özet |
| A new series of disulfonamides were synthesized and assayed as antimicrobial agents against Staphylococcus aureus, Bacillus cereus, and Escherichia coli. The quantitative structure-activity relationship analysis (QSAR) was applied to find out the correlation between experimentally evaluated antimicrobial activities with various parameters of the compounds using stepwise multiple liner regression method. The QSAR analysis revealed that the third-order average connectivity index ( 3 χ A ) was found to have negative correlation. The best QSAR models were further validated by leave-one-out method of cross-validation. © 2010 Springer Science+Business Media, LLC. |
| Anahtar Kelimeler |
| Antimicrobial activity | Disulfonamides | QSAR | Sulfonamides |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | MEDICINAL CHEMISTRY RESEARCH |
| Dergi ISSN | 1054-2523 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 03-2011 |
| Cilt No | 20 |
| Sayı | 2 |
| Sayfalar | 175 / 183 |
| Doi Numarası | 10.1007/s00044-010-9304-7 |
| Makale Linki | http://link.springer.com/10.1007/s00044-010-9304-7 |
| Atıf Sayıları | |
| WoS | 15 |
| SCOPUS | 16 |
| Google Scholar | 21 |
